Breast cancer is one of the leading causes of death that affects the female population
worldwide. Despite advances in treatments and a greater understanding of the disease …

Cancer vaccines need to be designed to effectively induce tumor-specific CD8+ T cells, the
key effector cells in immune responses against tumors. These T cells recognize peptides …

Tumor vaccine has been studied extensively as an alternative or adjuvant therapy in the
treatment of malignant tumors in the hope of prolonging the overall survival rates of cancer …

Tumor-associated self-antigens are potential cancer vaccine targets but suffer from limited
immunogenicity. There are examples of mutated, short self-peptides inducing epitope …

Gastric cancer is still one of the leading causes of cancer-related death worldwide.
Prevention and treatment of gastric cancer through vaccination has been difficult owing to …

Mimotopes are epitope-mimicking structures. When applied for immunizations they induce
desired antibody specificities exclusively based on the principle of molecular mimicry. This is …

After decades of cancer vaccine efforts, there is an imperious necessity for novel ideas that
may result in better tumor control in patients. We have proposed the use of a novel Variable …

Discovery of tumor antigenic epitopes is important for cancer vaccine development. Such
epitopes can be designed and modified to become more antigenic and immunogenic in …

Mimotopes of short CD8+ T-cell epitopes generally comprise one or more mutated residues,
and can increase the immunogenicity and function of peptide cancer vaccines. We recently …

Cytotoxic T-cells are the most important effector cells in immune responses against tumors.
The identification of tumor-associated epitopes for these cells, therefore, has become a key …