Methods To better understand the cross-talk betweenmTORand PC, we generated an in-
house PKD mouse model, Cd79a-Cre; Tsc1ff (Cd79a-Tsc1 KO hereafter), recapitulating …

Polycystic kidney disease (PKD) is a common genetic disorder arising from developmental
and postnatal processes. Defects in primary cilia and their signaling (eg, mTOR) underlie the …

Background: Polycystic kidney diseases (PKD) are a common genetic disorder arising from
developmental and/or postnatal processes. Defects of primary cilia and/or their signaling …

Polycystic kidney disease proteins, polycystin-1 and polycystin-2, localize to primary cilia.
Polycystin knockouts have severe cystogenesis compared to ciliary disruption, whereas …

Primary cilia play counterregulatory roles in cystogenesis—they inhibit cyst formation in the
normal renal tubule but promote cyst growth when the function of polycystins is impaired …

This proposal will study novel mTORC1 and 2 signaling pathways that mediate ADPKD and
investigate the effects of mTORC1 Raptor knockout, mTORC2 Rictor knockout or combined …

Progression of cystic kidney disease has been linked to activation of the mTORC1 signaling
pathway. Yet the utility of mTORC1 inhibitors to treat patients with polycystic kidney disease …

Background: Polycystic kidney disease (PKD) is intricately linked to the primary cilium. PKD1
and PKD2 encode for polycystin proteins which localize to cilia, and mutations in these …

The cell surface organelle called the cilium is essential for preventing kidney cyst formation
and for establishing left–right asymmetry of the vertebrate body plan. Recent advances …

Abstract Polycystin-2 (PC2, TRPP2) is a Ca2+ permeable non-selective cation channel
whose dysfunction generates autosomal dominant polycystic kidney disease (ADPKD). PC2 …