Fundamental questions on the pathogenesis of Alzheimer's disease (AD) are how nontoxic,
soluble amyloid β‐protein (Aβ) is converted to its toxic, aggregated form and how functional …

Alzheimer's disease (AD), the most common form of dementia, is characterized by the
progressive loss of neurons and synapses, and by extracellular deposits of amyloid‐β (Aβ) …

Epidemiological, animal, and cellular studies suggest that abnormalities in cholesterol
metabolism are important in the pathogenesis of Alzheimer's disease (AD), potentially by …

Cholesterol has been implicated in the pathogenesis of amyloid plaques in Alzheimer's
disease (AD) and in the formation of neurofibrillary pathology in Niemann‐Pick disease …

Evidence is accumulating to suggest that cholesterol is a potent risk factor for the
development of Alzheimer's disease. An increase in cholesterol level in neuronal …

Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's
disease (AD) bring cholesterol to the forefront of AD research. Research from genetics …

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease, both through
intracellular effects, and through an extracellular effect due to its physical interaction with …

The implication that cholesterol plays an essential role in the pathogenesis of Alzheimer's
disease (AD) is based on the 1993 finding that the presence of apolipoprotein E (apoE) …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

Cholesterol is an essential component of membranes for maintaining their structure and
functions. The discovery that possession of apolipoprotein E (apoE), allele ϵ4 is a strong …