An upstream open reading frame (uORF) signals for cellular localization of the virulence factor implicated in pregnancy associated malaria

Y Fastman, S Assaraf, M Rose, E Milrot… - Nucleic Acids …, 2018 - academic.oup.com
Plasmodium falciparum, the causative agent of the deadliest form of human malaria,
alternates expression of variable antigens, encoded by members of a multi-copy gene family …

An Upstream Open Reading Frame Controls Translation of var2csa, a Gene Implicated in Placental Malaria

B Amulic, A Salanti, T Lavstsen, MA Nielsen… - PLoS …, 2009 - journals.plos.org
Malaria, caused by the parasite Plasmodium falciparum, is responsible for substantial
morbidity, mortality and economic losses in tropical regions of the world. Pregnant women …

A molecular switch in the efficiency of translation reinitiation controls expression of var2csa, a gene implicated in pregnancy‐associated malaria

C Bancells, KW Deitsch - Molecular microbiology, 2013 - Wiley Online Library
P lasmodium falciparum malaria parasites export the protein PfEMP1 to the surface of
infected erythrocytes, enabling them to adhere to receptors in the microvasculature and …

Malaria var gene expression: keeping up with the neighbors

K Kim - Cell host & microbe, 2012 - cell.com
Plasmodium falciparum PfEMP1 is a malaria virulence protein whose expression is
epigenetically regulated. The parasite's ability to express exclusively only one of the sixty var …

Plasmodium falciparum Transcriptome Analysis Reveals Pregnancy Malaria Associated Gene Expression

N Tuikue Ndam, E Bischoff, C Proux, T Lavstsen… - PloS one, 2008 - journals.plos.org
Background Pregnancy-associated malaria (PAM) causing maternal anemia and low birth
weight is among the multiple manifestations of Plasmodium falciparum malaria. Infected …

Protein–RNA interactions important for Plasmodium transmission

KT Rios, SE Lindner - PLoS pathogens, 2019 - journals.plos.org
Gametocytes and sporozoites must both overcome similar obstacles. After fully maturing,
they must lie in wait and be prepared for a fleeting moment when a mosquito takes a blood …

The emerging role for RNA polymerase II in regulating virulence gene expression in malaria parasites

UE Ukaegbu, KW Deitsch - Plos Pathogens, 2015 - journals.plos.org
Plasmodium falciparum causes the most severe form of human malaria and is responsible
for a significant public health burden in the developing world. These protozoan parasites …

Unravelling a histone code for malaria virulence

CA Comeaux, MT Duraisingh - Molecular microbiology, 2007 - Wiley Online Library
Epigenetic phenomena have been shown to play a role in the regulated expression of
virulence genes in several pathogenic organisms, including the var gene family in …

A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo …

C Andradi-Brown, JS Wichers-Misterek, H von Thien… - Elife, 2024 - elifesciences.org
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …

The human malaria parasite genome is configured into thousands of coexpressed linear regulatory units

C Wang, J Gibbons, SR Adapa, J Oberstaller… - Journal of genetics and …, 2020 - Elsevier
The human malaria parasite Plasmodium falciparum thrives in radically different host
environments in mosquitoes and humans, with only a limited set of transcription factors. The …