Impact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

T Saito, Y Wei, L Wen, C Srinivasan, BO Wolthers… - Metabolomics, 2021 - Springer
Introduction Acute lymphoblastic leukemia (ALL) is among the most common cancers in
children. With improvements in combination chemotherapy regimens, the overall survival …

Biomarker identification and pathway analysis by serum metabolomics of childhood acute lymphoblastic leukemia

Y Bai, H Zhang, X Sun, C Sun, L Ren - Clinica Chimica Acta, 2014 - Elsevier
Background Acute lymphoblastic leukemia (ALL) is a common hematological malignant
neoplasm that typically affects children. Although intense chemotherapeutic regimens have …

Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia

JM Schraw, JP Woodhouse, MB Bernhardt… - Scientific Reports, 2021 - nature.com
Metabolomics may shed light on treatment response in childhood acute lymphoblastic
leukemia (ALL), however, most assessments have analyzed bone marrow or cerebrospinal …

[HTML][HTML] Metabolomics profiling reveals markers for chemosensitivity and clinical outcomes in pediatric AML patients

B Stockard, H Wu, JD Guingab, TJ Garrett, J Rubnitz… - Blood, 2018 - Elsevier
Acute myeloid leukemia (AML) is a clinically challenging disease with high interpatient
variability in response to chemotherapy. Despite continuing advances in treatment options …

Metabolomic profiling identifies pathways associated with minimal residual disease in childhood acute lymphoblastic leukaemia

JM Schraw, JJ Junco, AL Brown, ME Scheurer… - …, 2019 - thelancet.com
Background End-induction minimal residual disease (MRD) is the strongest predictor of
relapse in paediatric acute lymphoblastic leukaemia (ALL), but an understanding of the …

Metabolic profiling reveals metabolic features of consolidation therapy in pediatric acute lymphoblastic leukemia

J Fu, A Zhang, Q Liu, D Li, X Wang, L Si - Cancer & Metabolism, 2023 - Springer
Acute lymphoblastic leukemia (ALL) and its treatment continue to pose substantial risks. To
understand ALL more deeply, the metabolome in fasting plasma of 27 ALL patients before …

Metabolic Fingerprint in Childhood Acute Lymphoblastic Leukemia

MT Papadopoulou, P Panagopoulou, E Paramera… - Diagnostics, 2024 - mdpi.com
Introduction: Acute lymphoblastic leukemia (ALL) is the most prevalent childhood
malignancy. Despite high cure rates, several questions remain regarding predisposition …

Untargeted metabolomic and lipidomic analyses reveal lipid dysregulation in the plasma of acute leukemia patients

C Arévalo, L Rojas, M Santamaria, L Molina… - Frontiers in Molecular …, 2023 - frontiersin.org
Acute leukemias (AL) are aggressive neoplasms with high mortality rates. Metabolomics and
oxidative status have emerged as important tools to identify new biomarkers with clinical …

SERUM metabolomics of acute lymphoblastic leukaemia and acute myeloid leukaemia for probing biomarker molecules

SG Musharraf, AJ Siddiqui, T Shamsi… - Hematological …, 2017 - Wiley Online Library
Acute leukaemia (AL) is a critical neoplasm of white blood cells. Diagnosing AL requires
bone marrow puncture procedure, which many patients do not consent to for it is invasive …

Metabolomics of the tumor microenvironment in pediatric acute lymphoblastic leukemia

S Tiziani, Y Kang, R Harjanto, J Axelrod… - PloS one, 2013 - journals.plos.org
The tumor microenvironment is emerging as an important therapeutic target. Most studies,
however, are focused on the protein components, and relatively little is known of how the …