Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the
human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by …

Although it is now clear that reactive oxygen species (ROS) are not the key determinants of
longevity, a number of studies have highlighted the key role that these species play in age …

Physical frailty in the elderly is driven by loss of muscle mass and function and hence
preventing this is the key to reduction in age-related physical frailty. Our current …

Medical advancements have extended human life expectancy, which is not always
accompanied by an improved quality of life or healthspan. A decline in muscle mass and …

Skeletal muscle has the ability to adapt and remodel after functional, mechanical, and
metabolic stresses by activation of different adaptation mechanisms that induce gene …

Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and
intrinsic force production (quality). Along with decreased functional capacity of the muscle …

Age-associated frailty is predominantly due to loss of muscle mass and function. The loss of
muscle mass is also associated with a greater loss of muscle strength, suggesting that the …

Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

Ageing is associated with a progressive loss of skeletal muscle mass, quality and function—
sarcopenia, associated with reduced independence and quality of life in older generations …

Skeletal muscles comprise the largest organ system in the body and play an essential role in
body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important …