Impact of OATP transporters on pharmacokinetics

A Kalliokoski, M Niemi - British journal of pharmacology, 2009 - Wiley Online Library
Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …

Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption

Y Shitara, K Maeda, K Ikejiri, K Yoshida… - … & drug disposition, 2013 - Wiley Online Library
Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …

Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs

T Nakanishi, I Tamai - Drug metabolism and pharmacokinetics, 2012 - jstage.jst.go.jp
There is convincing evidence that many organic anion transporting polypeptide (OATP)
transporters influence the pharmacokinetics and pharmacological efficacy of their substrate …

Impact of genetic variation in OATP transporters to drug disposition and response

IY Gong, RB Kim - Drug metabolism and pharmacokinetics, 2013 - jstage.jst.go.jp
There has been remarkable progress during the past decade in understanding of how
genetic variations in drug metabolizing enzymes and transporters contribute to observed …

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

NF Smith, WD Figg, A Sparreboom - Expert opinion on drug …, 2005 - Taylor & Francis
Members of the organic anion transporting polypeptide (OATP) family are responsible for the
cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple …

Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1-and OATP1B3-mediated drug transport

J Kindla, F Müller, M Mieth, MF Fromm… - Drug metabolism and …, 2011 - ASPET
The transporter-mediated uptake of drugs from blood into hepatocytes is a prerequisite for
intrahepatic drug action or intracellular drug metabolism before excretion. Therefore, uptake …

Role of OATP transporters in the disposition of drugs

M Niemi - Pharmacogenomics, 2007 - Taylor & Francis
During recent years, it has become increasingly recognized that drug transporters play
important roles in drug absorption and disposition. Organic anion transporting polypeptides …

Organic anion‐transporting polypeptide (OATP) transporter family and drug disposition

RB Kim - European journal of clinical investigation, 2003 - Wiley Online Library
Drug transporters are increasingly recognized as a key determinant of drug disposition.
Recent studies have revealed that targeted expression of drug uptake and efflux …

Uptake transporters of the human OATP family: molecular characteristics, substrates, their role in drug–drug interactions, and functional consequences of …

J König - Drug Transporters, 2011 - Springer
Organic anion transporting polypeptides (OATPs, gene family: SLC21/SLCO) mediate the
uptake of a broad range of substrates including several widely prescribed drugs into cells …

Meta-analysis of expression of hepatic organic anion–transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue

J Badée, B Achour, A Rostami-Hodjegan… - Drug Metabolism and …, 2015 - ASPET
Organic anion–transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 transporters
play an important role in hepatic drug disposition. Recently, an increasing number of studies …