H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However, the recent emergence of the Omicron variant has posed a challenge, as it evades detection …
AC Fagre, J Manhard, R Adams, M Eckley… - Frontiers in …, 2020 - frontiersin.org
The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir …
M Takeshita, H Fukuyama, K Kamada, T Matsumoto… - Iscience, 2022 - cell.com
The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been highly effective. However, there remain few practical antibodies against viruses that are …
Y Huang, H Sun, H Yu, S Li, Q Zheng… - Antibody …, 2020 - academic.oup.com
The rapid emergence of Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent …
N Hingankar, S Deshpande, P Das, ZA Rizvi… - PLoS …, 2022 - journals.plos.org
Although efficacious vaccines have significantly reduced the morbidity and mortality of COVID-19, there remains an unmet medical need for treatment options, which monoclonal …
Summary SARS-CoV-2 neutralizing antibodies (NAbs) protect against COVID-19, making them a focus of vaccine design. A safety concern regarding SARS-CoV-2 antibodies is …
W Su, SF Sia, AJ Schmitz, TL Bricker, TN Starr… - MBio, 2021 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein is the main target for neutralizing antibodies. These antibodies can be elicited through …
Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 …
CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID- 19, little is known about their mechanism (s) of action or effective dosing windows. We report …