Little is known about the time-dependent immune responses in severe COVID-19. Data of
15 consecutive patients were sequentially recorded from intensive care unit admission …

Background In critically ill COVID-19 patients, the initial response to SARS-CoV-2 infection
is characterized by major immune dysfunctions. The capacity of these severe patients to …

The spectrum of coronavirus disease 2019 (COVID-19) severity, related to cellular immune
functions, has not been fully clarified yet. Therefore, this study aimed to investigate the …

SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

Abstract Background Coronavirus disease 2019 (COVID-19) is affecting the whole world
and threatening human health. We aim to investigate the immunological characteristics of …

The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an
impact on the course of COVID-19, and play a role in the clinical outcome of the disease …

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …

Recently, the novel coronavirus disease (COVID-19) has broken out worldwide, 1 with rapid
increase of infected patients. COVID-19 dominantly leads to pneumonia. 2 Among these …

BACKGROUND Patients infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS …

Background SARS‐CoV‐2 has triggered a pandemic that is now claiming many lives.
Several studies have investigated cellular immune responses in COVID‐19‐infected …