Variant histone H3. 3 is incorporated into nucleosomes by a mechanism that does not
require DNA replication and has also been implicated as a potential mediator of epigenetic …

Chromatin states can be distinguished by differential covalent modifications of histones or by
utilization of histone variants. Chromatin associated with transcriptionally active loci …

Deposition of variant histones provides a mechanism to reset and to potentially specify
chromatin states. We determined the distribution of H3 and its variant H3. 3 relative to …

Histones are the fundamental components of the nucleosome. Physiologically relevant
variation is introduced into this structure through chromatin remodeling, addition of covalent …

DNA in eukaryotic cells is packaged into nucleosomes, the structural unit of chromatin. Both
DNA and bulk histones are extremely long-lived, because old DNA strands and histones are …

Histone proteins wrap DNA to form nucleosome particles that compact eukaryotic genomes
while still allowing access for cellular processes such as transcription, replication and DNA …

The nucleosomal organization of eukaryotic chromatin is generally established during DNA
replication by the deposition of canonical histones synthesized in S phase. However, cells …

The H3. 3 histone variant is synthesized throughout cell cycle and deposited onto chromatin
in a replication-independent manner. It is enriched in transcriptionally active regions of …

The importance of histone H1 heterogeneity and total H1 stoichiometry in chromatin has
been enigmatic. Here we report a detailed characterization of the chromatin structure of cells …

Post-translation modifications of histones modulate the accessibility and transcriptional
competence of specific chromatin regions within the eukaryotic genome. Phosphorylation of …