Molnupiravir: A new candidate for COVID‐19 treatment

F Pourkarim, S Pourtaghi‐Anvarian… - Pharmacology …, 2022 - Wiley Online Library
The novel coronavirus disease 2019 (COVID‐19) emerged in late December 2019 in china
and has rapidly spread to many countries around the world. The effective pharmacotherapy …

Molnupiravir and its antiviral activity against COVID-19

L Tian, Z Pang, M Li, F Lou, X An, S Zhu… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat …

Molnupiravir and nirmatrelvir/ritonavir: tolerability, safety, and adherence in a retrospective cohort study

M Mazzitelli, D Mengato, L Sasset, A Ferrari, S Gardin… - Viruses, 2023 - mdpi.com
Background. Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) were recently approved for
the early treatment of COVID-19, but real-life data on tolerability, safety, and adverse events …

Molnupiravir: first approval

YY Syed - Drugs, 2022 - Springer
Molnupiravir (Lagevrio®) is an orally-administered antiviral prodrug that inhibits replication
of RNA viruses through viral error induction. It is being developed by Merck and Ridgeback …

Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs

LD Saravolatz, S Depcinski… - Clinical Infectious …, 2023 - academic.oup.com
At a crucial time with rapid spread of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variant globally, the United States Food and Drug Administration …

Combined treatment of molnupiravir and favipiravir against SARS-CoV-2 infection: One+ zero equals two?

P Eloy, R Le Grand, D Malvy, J Guedj - EBioMedicine, 2021 - thelancet.com
The route to an effective antiviral treatment against SARS-CoV-2 has been marked by
dozens of negative clinical trials, with thousands of patients across the globe enrolled in …

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

R Abdelnabi, CS Foo, SJF Kaptein, X Zhang… - …, 2021 - thelancet.com
Abstract Background Favipiravir and Molnupiravir, orally available antivirals, have been
reported to exert antiviral activity against SARS-CoV-2. First efficacy data have been recently …

Molnupiravir and risk of post-acute sequelae of covid-19: cohort study

Y Xie, T Choi, Z Al-Aly - bmj, 2023 - bmj.com
Objective To examine whether treatment with the antiviral agent molnupiravir during the first
five days of SARS-CoV-2 infection is associated with reduced risk of post-acute adverse …

Early clinical experience with molnupiravir for mild to moderate breakthrough COVID-19 among fully vaccinated patients at risk for disease progression

A Vena, L Traman, M Bavastro, A Limongelli… - Vaccines, 2022 - mdpi.com
Information on the efficacy and safety of molnupiravir in daily clinical practice is very scarce.
We aimed to describe the clinical characteristics and outcomes of fully vaccinated patients …

543. Molnupiravir maintains antiviral activity against SARS-CoV-2 variants in vitro and in early clinical studies

J Grobler, J Strizki, N Murgolo, W Gao… - Open forum …, 2021 - academic.oup.com
Abstract Background Molnupiravir (MOV, MK-4482, EIDD-2801) is an orally administered
prodrug of N-hydroxycytidine (NHC, EIDD-1931), a nucleoside with broad antiviral activity …