Targeting lower motor neurons (LMNs) for gene delivery could be useful for disorders such
as spinal muscular atrophy and amyotrophic lateral sclerosis. LMNs reside in the ventral …

The peripheral nervous system (PNS), including peripheral nerves and dorsal root ganglion
(DRG), is involved in numerous neurological disorders, such as peripheral neuropathies …

The architecture of the spinal cord makes efficient delivery of recombinant adeno-associated
virus (rAAV) vectors throughout the neuraxis challenging. We describe a paradigm in which …

Adeno-associated virus 6 (AAV6) has been proposed as a potential vector candidate for
specific gene expression in pain-related dorsal root ganglion (DRG) neurons, but this has …

Neurotropic adeno-associated virus (AAV) serotypes such as AAV9 have been
demonstrated to transduce spinal alpha motor neurons when administered intravenously (iv) …

Gene therapy for motor neuron diseases requires efficient gene delivery to motor neurons
(MNs) throughout the spinal cord and brainstem. The present study compared adeno …

In the context of motoneuron diseases, gene delivery as an experimental or therapeutic
approach is hindered by the challenge to specifically target cell populations that are widely …

Preclinical studies have demonstrated that a single injection of an adeno-associated virus
(AAV) vector into the cerebrospinal fluid (CSF) can achieve widespread gene transfer …

Background: Neuronal transduction by adeno-associated viral (AAV) vectors has been
demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of …

Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a
promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic …