Association between the BDNF Val66Met polymorphism and major depressive disorder: a systematic review and meta-analysis

Y Wang, O Li, N Li, Z Sha, Z Zhao, J Xu - Frontiers in Psychiatry, 2023 - frontiersin.org
Study objectives This meta-analysis analytically reviewed recent studies concerning the
potential associations between the brain-derived neurotrophic factor (BDNF) Val66Met …

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

M Verhagen, A Van Der Meij, PAM Van Deurzen… - Molecular …, 2010 - nature.com
Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-
like effects in animals and may be implicated in the etiology of mood-related phenotypes …

No association of genetic variants in BDNF with major depression: A meta‐ and gene‐based analysis

JP Gyekis, W Yu, S Dong, H Wang… - American Journal of …, 2013 - Wiley Online Library
Major depressive disorder (MDD) is a complex psychiatric condition with strong genetic
predisposition. The association of MDD with genetic polymorphisms, such as Val66Met …

Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study

A Terracciano, MG Piras, M Lobina… - The World Journal of …, 2013 - Taylor & Francis
Objectives. Lower levels of serum brain derived neurotrophic factor (BDNF) is one of the
best known biomarkers of depression. To identify genetic variants associated with serum …

Genetic association study of BDNF in depression: Finding from two cohort studies and a meta‐analysis

L Chen, DA Lawlor, SJ Lewis, W Yuan… - American Journal of …, 2008 - Wiley Online Library
Depression is common and a major cause of morbidity and mortality and is also known to
have serious effects on quality of life. Both clinical and pharmacologic studies have …

Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis

GM Hosang, C Shiles, KE Tansey, P McGuffin, R Uher - BMC medicine, 2014 - Springer
Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …

Influence of BDNF Val66Met genetic polymorphism in Major Depressive Disorder and Body Mass Index: Evidence from a meta-analysis of 6481 individuals

AM Pérez-Gutiérrez, P Rovira, B Gutiérrez… - Journal of Affective …, 2024 - Elsevier
Background Major depressive disorder (MDD) and obesity are global health problems that
frequently co-occur. Among shared etiological factors, genetic variation at the brain-derived …

Brain-derived neurotrophic factor and major depressive disorder: evidence from meta-analyses

T Kishi, R Yoshimura, T Ikuta, N Iwata - Frontiers in psychiatry, 2018 - frontiersin.org
Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is
associated with the pathophysiology of major depressive disorder (MDD). In this mini review …

Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population

R Suchanek, A Owczarek, M Kowalczyk… - Journal of Molecular …, 2011 - Springer
According to neurotrophic hypothesis, brain-derived neurotrophic factor (BDNF) is the
potential candidate involved in the pathogenesis of depression. We examined the influence …

Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders

E Lin, PS Chen, LC Huang, SY Hsu - … and personalized medicine, 2008 - Taylor & Francis
Major depressive disorder (MDD) is one of the most common mental disorders worldwide.
Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to …