Background and Purpose—Increased blood–brain barrier (BBB) permeability occurs in
cerebral small vessel disease. It is not known if BBB changes predate progression of small …

Blood–brain barrier (BBB) dysfunction is one of the pathophysiological mechanisms in
cerebral small vessel disease (SVD). Previously, it was shown that BBB leakage volume is …

Objective Several studies have demonstrated that compromised blood–brain barrier (BBB)
integrity may play a pivotal role in the pathogenesis of individual cerebral small vessel …

Background and Purpose—The blood–brain barrier (BBB) is disrupted in small vessel
disease patients with lacunes and white matter hyperintensities (WMHs). The relationship of …

Cerebral small vessel disease (cSVD) comprises pathological processes of the small
vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or …

Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …

Objective: In patients with acute ischemic stroke, we aimed to investigate the relation
between preexisting small vessel disease (SVD) and the amount of blood–brain barrier …

Background and Purpose—Cerebral small-vessel disease and cerebral blood flow (CBF)
are interrelated. However, the direction of the relationship is unknown, and longitudinal …

Objective To investigate the link between blood-brain-barrier (BBB) permeability and
cerebral blood flow (CBF) and the relation with white matter hyperintensities (WMH) in …

Background and aim The pathogenesis of cerebral small-vessel disease (SVD) is
incompletely understood. Endothelial dysfunction has been implicated and may result in …