New insights into SARS-CoV-2 brain infection and olfactory impairment in the hamster model

J Ferreira - Lab Animal, 2023 - nature.com
Many people are still being infected with COVID-19, and many more are still suffering from
its long-lasting effects. Despite a large amount of research on the mechanisms that explain …

The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models

R Butowt, N Meunier, B Bryche, CS von Bartheld - Acta neuropathologica, 2021 - Springer
One of the most frequent symptoms of COVID-19 is the loss of smell and taste. Based on the
lack of expression of the virus entry proteins in olfactory receptor neurons, it was originally …

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

GD de Melo, V Perraud, F Alvarez… - Nature …, 2023 - nature.com
Anosmia was identified as a hallmark of COVID-19 early in the pandemic, however, with the
emergence of variants of concern, the clinical profile induced by SARS-CoV-2 infection has …

Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

M Kishimoto-Urata, S Urata, R Kagoya, F Imamura… - Scientific reports, 2022 - nature.com
The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points
using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory …

Severe acute respiratory syndrome coronavirus 2 infects and damages the mature and immature olfactory sensory neurons of hamsters

AJ Zhang, ACY Lee, H Chu, JFW Chan… - Clinical infectious …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) is primarily an acute respiratory
tract infection. Distinctively, a substantial proportion of COVID-19 patients develop olfactory …

Long COVID: From olfactory dysfunctions to viral Parkinsonism

S Pandey, V Bapat, JN Abraham… - World Journal of …, 2024 - mednexus.org
Neurological and psychiatric complications continue to be a public health concern in long
coronavirus disease 2019 (COVID-19). This varies from olfactory dysfunctions such as …

Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection

R Butowt, CS von Bartheld - The Neuroscientist, 2021 - journals.sagepub.com
In recent months it has emerged that the novel coronavirus—responsible for the COVID-19
pandemic—causes reduction of smell and taste in a large fraction of patients. The …

COVID-19-associated olfactory dysfunction reveals SARS-CoV-2 neuroinvasion and persistence in the olfactory system

GD De Melo, F Lazarini, S Levallois, C Hautefort… - BioRxiv, 2020 - biorxiv.org
While recent investigations have revealed viral, inflammatory and vascular factors involved
in SARS-CoV-2 lung pathogenesis, the pathophysiology of neurological disorders in COVID …

Effects of COVID-19 on the human central olfactory system: A natural pre-post experiment

E Thunell, MG Peter, V Lenoir… - American Journal …, 2022 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Reduced olfactory function is the symptom with the
highest prevalence in coronavirus disease 2019 (COVID-19) with nearly 70% of infected …

SARS-CoV-2: The Road Less Traveled—From the Respiratory Mucosa to the Brain

JP Arunachalam, A UR, K Verma, R Rajendran… - ACS …, 2021 - ACS Publications
Neurological manifestations have been reported in COVID-19; however, the route used by
SARS-CoV-2 to enter the brain is still under debate. Recent studies have focused on the …