OBJECTIVE To determine 1) whether renal arginase activity or expression is increased in
diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN) …

Recently, we showed that pharmacological blockade or genetic deficiency of arginase-2
confers kidney protection in diabetic mouse models. Here, we tested whether the protective …

Our previous publication showed that inhibition of arginase prevents the development of
diabetic nephropathy (DN). However, identification of targets that retard the progression of …

Novel therapeutic interventions for preventing or attenuating kidney injury following
ischemia-reperfusion injury (IRI) remain a focus of significant interest. Currently, there are no …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Our recent publication showed that pharmacological blockade of arginases confers kidney
protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS) 3-dependent …

Enhanced arginase (ARG) activity has been identified as a factor that reduces nitric oxide
production and impairs endothelial function in vascular pathologies. Using a gene deletion …

Kidney ischemia–reperfusion injury is a major cause of acute kidney injury (AKI). Following
reduced kidney perfusion, the pathological overproduction of reactive oxygen and reactive …

There is growing evidence that vascular arginase plays a role in pathophysiology of
vascular diseases. We recently reported high arginase activity/expression in young adult …

Background Cardiovascular disorders associated with endothelial dysfunction, such as
atherosclerosis, have decreased nitric oxide (NO) bioavailability. Arginase in the vasculature …