Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

JL Torres, G Ozorowski, E Andreano… - Proceedings of the …, 2022 - National Acad Sciences
As the coronavirus disease 2019 (COVID-19) pandemic continues, there is a strong need for
highly potent monoclonal antibodies (mAbs) that are resistant against severe acute …

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

H Liu, NC Wu, M Yuan, S Bangaru, JL Torres… - Immunity, 2020 - cell.com
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition

KJ Kramer, NV Johnson, AR Shiakolas, N Suryadevara… - Cell Reports, 2021 - cell.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages
that are more transmissible and resistant to currently approved antibody therapies poses a …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

Structure-guided antibody cocktail for prevention and treatment of COVID-19

SC Su, TJ Yang, PY Yu, KH Liang, WY Chen… - PLoS …, 2021 - journals.plos.org
Development of effective therapeutics for mitigating the COVID-19 pandemic is a pressing
global need. Neutralizing antibodies are known to be effective antivirals, as they can be …

[HTML][HTML] The antigenic anatomy of SARS-CoV-2 receptor binding domain

W Dejnirattisai, D Zhou, HM Ginn, HME Duyvesteyn… - Cell, 2021 - cell.com
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency
use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) …

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

X Wang, A Hu, X Chen, Y Zhang, F Yu, S Yue… - … and Targeted Therapy, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic of novel coronavirus disease (COVID-19). The neutralizing monoclonal …

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

D Fu, G Zhang, Y Wang, Z Zhang, H Hu, S Shen… - PLoS …, 2021 - journals.plos.org
The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) threatens global public health and …

Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections

C Zhang, Y Wang, Y Zhu, C Liu, C Gu, S Xu… - Nature …, 2021 - nature.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Neutralizing antibodies against SARS …

Structural changes in the SARS-CoV-2 spike E406W mutant escaping a clinical monoclonal antibody cocktail

A Addetia, YJ Park, T Starr, AJ Greaney, KR Sprouse… - Cell Reports, 2023 - cell.com
Continued evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
eroding antibody responses elicited by prior vaccination and infection. The SARS-CoV-2 …