Tutorial: a guide to performing polygenic risk score analyses
SW Choi, TSH Mak, PF O'Reilly - Nature protocols, 2020 - nature.com
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual's
genetic liability to a trait or disease, calculated according to their genotype profile and …
genetic liability to a trait or disease, calculated according to their genotype profile and …
Will polygenic risk scores for cancer ever be clinically useful?
Genome-wide association studies (GWAS) have identified associations between common
genetic variants, single nucleotide polymorphisms (SNPs) and the risk of developing …
genetic variants, single nucleotide polymorphisms (SNPs) and the risk of developing …
Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues
ACF Lewis, RC Green - Genome Medicine, 2021 - Springer
Clinical use of polygenic risk scores (PRS) will look very different to the more familiar
monogenic testing. Here we argue that despite these differences, most of the ethical, legal …
monogenic testing. Here we argue that despite these differences, most of the ethical, legal …
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common
diseases,–. We estimated their added value in clinical risk prediction of five common …
diseases,–. We estimated their added value in clinical risk prediction of five common …
[HTML][HTML] Current clinical use of polygenic scores will risk exacerbating health disparities
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …
medicine. However, the major ethical and scientific challenge surrounding clinical …
Towards clinical utility of polygenic risk scores
Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …
management. Risk prediction typically includes risk factors such as age, sex, family history of …
Clinical use of current polygenic risk scores may exacerbate health disparities
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …
medicine. However, the major ethical and scientific challenge surrounding clinical …
[PDF][PDF] Polygenic risk scores in the clinic: translating risk into action
Polygenic risk scores (PRSs) are heralded as useful tools for risk stratification and
personalized preventive care, but they are clinically useful only if they can be translated into …
personalized preventive care, but they are clinically useful only if they can be translated into …
The emerging field of polygenic risk scores and perspective for use in clinical care
Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …
diseases. Until recently, there were no genetic testing options available for multifactorial …
[PDF][PDF] Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …
few studies have thoroughly investigated their best practices in global populations across …