[HTML][HTML] Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms

C Stonesifer, S Corey, S Ghanekar, Z Diamandis… - Progress in …, 2017 - Elsevier
Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Neuroinflammation, stem cells, and stroke

S Anthony, D Cabantan, M Monsour, CV Borlongan - Stroke, 2022 - Am Heart Assoc
Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells

BRS Broughton, R Lim, TV Arumugam… - Frontiers in cellular …, 2013 - frontiersin.org
Ischemic stroke is a debilitating disease for which there are currently no effective treatments
besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less …

Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury

B Bonsack, S Corey, A Shear, M Heyck… - CNS neuroscience & …, 2020 - Wiley Online Library
Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and
costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death …

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms

M Bacigaluppi, S Pluchino, LP Jametti, E Kilic, Ü Kilic… - Brain, 2009 - academic.oup.com
Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in
animal models with delayed neuronal death via a number of indirect bystander effects. A …

Efficacy of stem cell-based therapies for stroke

MR Chrostek, EG Fellows, AT Crane, AW Grande… - Brain research, 2019 - Elsevier
Stroke remains a prevalent disease with limited treatment options. Available treatments offer
little in the way of enhancing neurogenesis and recovery. Because of the limitations of …

Cell therapy for chronic stroke

LR Wechsler, D Bates, P Stroemer… - Stroke, 2018 - Am Heart Assoc
2 Stroke May 2018 produce a host of angiogenic factors. 23–26 The enhancement of
endogenous neurogenesis stimulated by brain injury has been shown for mesenchymal …

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

EW Baker, HA Kinder, FD West - Brain and behavior, 2019 - Wiley Online Library
Abstract Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic
function for stroke, which is the leading cause of long‐term disability and the second leading …

Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here

MK Tobin, JA Bonds, RD Minshall… - Journal of Cerebral …, 2014 - journals.sagepub.com
This review covers the pathogenesis of ischemic stroke and future directions regarding
therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …

Mesenchymal stem cells: therapeutic outlook for stroke

O Honmou, R Onodera, M Sasaki, SG Waxman… - Trends in molecular …, 2012 - cell.com
Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of
functional properties. Transplantation of these cells improves clinical outcome in models of …