S Anthony, D Cabantan, M Monsour, CV Borlongan - Stroke, 2022 - Am Heart Assoc
Stroke remains a significant unmet clinical need with few treatment options that have a very narrow therapeutic window, thereby causing massive mortality and morbidity in the United …
Ischemic stroke is a debilitating disease for which there are currently no effective treatments besides the clot-buster, tissue plasminogen activator (t-PA), which is administered to less …
B Bonsack, S Corey, A Shear, M Heyck… - CNS neuroscience & …, 2020 - Wiley Online Library
Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death …
Recent evidence suggests that neural stem/precursor cells (NPCs) promote recovery in animal models with delayed neuronal death via a number of indirect bystander effects. A …
Stroke remains a prevalent disease with limited treatment options. Available treatments offer little in the way of enhancing neurogenesis and recovery. Because of the limitations of …
LR Wechsler, D Bates, P Stroemer… - Stroke, 2018 - Am Heart Assoc
2 Stroke May 2018 produce a host of angiogenic factors. 23–26 The enhancement of endogenous neurogenesis stimulated by brain injury has been shown for mesenchymal …
EW Baker, HA Kinder, FD West - Brain and behavior, 2019 - Wiley Online Library
Abstract Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the second leading …
This review covers the pathogenesis of ischemic stroke and future directions regarding therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …
O Honmou, R Onodera, M Sasaki, SG Waxman… - Trends in molecular …, 2012 - cell.com
Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of …