Multidrug resistance represents a major obstacle in the successful therapy of neoplastic
diseases. Studies have demonstrated that this form of drug resistance occurs both in …

P-glycoprotein is a molecule strongly associated with multi-drug resistance to certain
cytostatic drugs, including adriamycin, vincristine, and daunorubicin. Using 3 monoclonal …

Multidrug resistance describes a complex phenotype whose predominant feature is
resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are …

HE PRINCIPAL reason for treatment failure in patients T with cancer is the presence of
disease that is disseminated and resistant to therapy. Clinical resistance to anticancer …

Multidrug resistance (MDR) is a unique phenomenon in thc study of cellular drug resistance.
Cell lines exhibiting this phenotype have been selected for resistance to a single cytotoxic …

The resistance of human malignancy to multiple chemotherapeutic agents remains a major
obstacle in cancer therapy. Resistance has been termed intrinsic when the tumor initially …

Human cancer cells selected for resistance to multiple hydrophobic cytotoxic drugs express
the cell surface P-glycoprotein, which is the product of the MDRl gene. In this review Michael …

The development of simultaneous resistance to multiple drugs in cultured cells occurs after
selection for resistance to single agents. This multidrug-resistance phenotype is thought to …

The ability of tumor cells to develop simultaneous resistance to multiple lipophilic cytotoxic
compounds represents a major problem in cancer chemotherapy. This review describes …

Advances in chemotherapeutic treatment of human cancers will depend on our acquiring a
real understanding of what factors limit successful therapy. One factor postulated to be …