Paeonol exerts neuroprotective and anticonvulsant effects in intrahippocampal kainate model of temporal lobe epilepsy

S Ramazi, J Fahanik-Babaei… - Journal of Chemical …, 2022 - Elsevier
Temporal lobe epilepsy (TLE) is presented the most common form of focal epilepsy with
involvement of oxidative stress and neuroinflammation as important factors in its …

Neuroprotective and anticonvulsant effects of sinomenine in kainate rat model of temporal lobe epilepsy: Involvement of oxidative stress, inflammation and pyroptosis

S Ramazi, J Fahanik-Babaei… - Journal of chemical …, 2020 - Elsevier
Oxidative stress, inflammation and pyroptosis are three of the most important mechanisms in
the pathophysiology of temporal lobe epilepsy (TLE). Most people with TLE are refractory to …

Anticonvulsant and neuroprotective effects of paeonol in epileptic rats

DH Liu, E Agbo, SH Zhang, JL Zhu - Neurochemical Research, 2019 - Springer
Paeonol is the main active compound in the root bark extract of the peony tree, and it has
antioxidative and anti-inflammatory effects. Recent studies have reported the …

Alpha-pinene exerts antiseizure effects by preventing oxidative stress and apoptosis in the hippocampus in a rat model of temporal lobe epilepsy induced by kainate

P Hashemi, S Ahmadi - Molecular Neurobiology, 2023 - Springer
Oxidative stress and apoptosis following seizures play pivotal roles in the consequences of
repeated seizures. Beneficial effects of alpha-pinene (APN) have been reported in some …

Huperzine A ameliorates cognitive dysfunction and neuroinflammation in kainic acid‐induced epileptic rats by antioxidant activity and NLRP 3/caspase‐1 pathway …

P Mohseni‐Moghaddam, SS Sadr… - Clinical and …, 2019 - Wiley Online Library
Temporal lobe epilepsy (TLE) is one of the most prevalent types of epilepsy in human.
Huperzine A (Hup‐A) has been reported to possess antioxidative and anti‐inflammatory …

Thymoquinone attenuates astrogliosis, neurodegeneration, mossy fiber sprouting, and oxidative stress in a model of temporal lobe epilepsy

S Dariani, T Baluchnejadmojarad… - Journal of Molecular …, 2013 - Springer
Temporal lobe epilepsy (TLE) is a rather common and difficult-to-treat variant of epilepsy.
Nearly one third of people with epilepsy do not respond effectively to currently available …

The potential neuroprotective roles of olive leaf extract in an epilepsy rat model induced by kainic acid

S Khamse, SM Haftcheshmeh, SS Sadr… - Research in …, 2021 - journals.lww.com
Background and purpose: Epilepsy is recognized as a chronic neurologic disease.
Increasing evidence has addressed the antioxidant and anti-inflammatory roles of olive leaf …

Alpha-Pinene Decreases the Elevated Levels of Astrogliosis, Pyroptosis, and Autophagy Markers in the Hippocampus Triggered by Kainate in a Rat Model of …

P Hashemi, P Mardani, Z Eghbali Raz, A Saedi… - Molecular …, 2024 - Springer
The development and progression of temporal lobe epilepsy (TLE) are heavily influenced by
inflammation, excessive activation of glial cells, and neuronal cell death. This study aimed to …

Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway

Z Liu, C Yang, X Meng, Z Li, C Lv, P Cao - Neurochemistry international, 2018 - Elsevier
Epilepsy is a severe and chronic neurological disease. Edaravone is an effective free radical
scavenger and has been reported to prevent neuronal loss induced by Kainate (KA) …

Ferulic acid attenuates kainate-induced neurodegeneration in a rat poststatus epilepticus model

AJ Suha, SS Sadr, M Roghani… - Current molecular …, 2023 - ingentaconnect.com
Background and Aims: Increasing research evidence indicates that temporal lobe epilepsy
(TLE) induced by kainic acid (KA) has high pathological similarities with human TLE. KA …