Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art

L Stejskalova, Z Dvorak, P Pavek - Current drug metabolism, 2011 - ingentaconnect.com
Aryl hydrocarbon receptor (AhR) is an important transcriptional regulator of drug
metabolizing enzymes that dominantly controls the expression of cytochrome P450 CYP1 …

Ligands and agonists of the aryl hydrocarbon receptor AhR: Facts and myths

L Sládeková, S Mani, Z Dvořák - Biochemical Pharmacology, 2023 - Elsevier
The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

ÁC Roman, JM Carvajal-Gonzalez, JM Merino… - Pharmacology & …, 2018 - Elsevier
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …

[HTML][HTML] Aryl hydrocarbon receptor (AHR) ligands as selective AHR modulators (SAhRMs)

S Safe, U Jin, H Park, RS Chapkin… - International journal of …, 2020 - mdpi.com
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

Ligand-dependent and-independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models

RS Pollenz, C Buggy - Chemico-biological interactions, 2006 - Elsevier
Studies have shown that zebrafish and rodent aryl hydrocarbon receptors (AHRs) are
degraded following ligand exposure and that reductions in AHR protein can impact growth …

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

E Guyot, A Chevallier, R Barouki, X Coumoul - Drug discovery today, 2013 - Elsevier
The aryl hydrocarbon receptor (AhR) is a transcription factor which is activated by diverse
compounds and regulates the expression of xenobiotic metabolism genes. Recent studies …

Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor

PA Harper, DS Riddick, AB Okey - Biochemical pharmacology, 2006 - Elsevier
The aryl hydrocarbon receptor (AHR) participates in a wide range of critical cellular events in
response to endogenous signals or xenobiotic chemicals. Hence, it is important that AHR …

Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway

NC Sondermann, S Faßbender, F Hartung… - Biochemical …, 2023 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …

The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe?

TD Bradshaw, V Trapani, DA Vasselin… - Current …, 2002 - ingentaconnect.com
Binding of ligands such as polycyclic aromatic hydrocarbons to the Aryl hydrocarbon
Receptor (AhR) and the sequence of events leading to induction of xenobiotic-metabolising …

The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways

C Ma, JL Marlowe, A Puga - Molecular, Clinical and Environmental …, 2009 - Springer
The aryl hydrocarbon receptor (AHR) has long been recognized as a ligand-activated
transcription factor responsible for the induction of drug-metabolizing enzymes. Its role in the …