In Mammals, kidney development proceeds in three stages (reviewed in 1). The first two
stages lead to the formation of transient structures, the pronephros and the mesonephros …

Genetically engineered mice have provided much information about gene function in the
field of developmental biology. Recently, conditional gene targeting using the Cre/loxP …

The metanephric, or definitive, kidney forms as a result of inductive processes between
tissues of two distinct embryologic orgins, the metanephric mesenchymal blastema and the …

Embryonic metanephroi, differentiating into the adult kidney, have come to be a generally
accepted model system for organogenesis. Nephrogenesis implies a highly controlled …

The molecular regulation of the complex inductive events associated with formation of the
vertebrate excretory system has been progressively elucidated as a result of both genetic …

Branching morphogenesis, mesenchymal cell condensation and mesenchymal-to-epithelial
conversion are key steps in kidney development and morphogenesis of several other …

The development of the mature mammalian kidney begins with the invasion of metanephric
mesenchyme by ureteric bud. Mesenchymal cells near the bud become induced and convert …

Kidney epithelia develop from the metanephric mesenchyme after receiving inductive
signals from the ureteric bud and from the renal stroma. However, it is not clear how these …

The development of the mammalian kidney is a complex and in part unknown process which
requires interactions between pluripotential/stem cells, undifferentiated mesenchymal cells …

Growth and expansion of the embryonic kidney is driven in large part by continuous
branching morphogenesis and nephron induction that occurs in a restricted domain beneath …