Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

The first line of defense against viral infections is mediated by interferons (IFN) s, which are
produced rapidly by the infected host. Type I IFNs (IFN-α/β) are known to combat viruses …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …

Cytokines are small secreted molecules, which mediate cross‐talk between cells involved in
the immune response. Interferons (IFN) s, constitute a class of cytokines with antiviral …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Viral infections trigger innate immune responses, including the production of type I
interferons (IFN-α and-β) and other proinflammatory cytokines. Novel antiviral cytokines IFN …

Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …

Abstract Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities,
which remain poorly characterized. We herein show that most cell types expressed both …

Type III interferons (IFNs), also termed lambda IFNs (IFNλs) or interleukins-28/29, constitute
a new addition to the IFN family. They are induced upon infection and are particularly …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …