Summary As Current Opinion, this monograph seeks to summarize, and provoke, new
EPO/EPOR action concepts. Specific problems addressed include: beyond (and before) …

Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their
survival and for their quantitatively regulated transition to red blood cells. With regard to Epo …

Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

As essential mediators of red cell production, erythropoietin (EPO) and its cell surface
receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined …

The erythropoietin receptor (EPOR) is crucial for promoting the survival, proliferation, and
differentiation of mammalian erythroid progenitors [1]. Differentiation from colony-forming …

Erythropoietin (EPO), a humoral regulator of erythropoiesis and replacement therapy for
selected red blood cell disorders in EPO-deficient patients, has been implicated in a wide …

A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has
emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …

Signals provided by the erythropoieitin receptor (EpoR) are required for erythroid
development beyond the erythroid colony-forming unit (CFU-e) stage and are propagated …

Critical signals for erythroblast formation are transduced by activated, tyrosine-
phosphorylated erythropoietin receptor (EpoR) complexes. Nonetheless, steady-state …

Erythropoietin (Epo) and its receptor (EpoR) are essential for proliferation, differentiation and
survival of erythroid progenitors. Here, we review several mechanisms by which the EpoR …