Aryl hydrocarbon receptor (AHR) functions in NAD+ metabolism, myelopoiesis and obesity

KW Bock - Biochemical pharmacology, 2019 - Elsevier
Diverse physiologic functions of AHR, a transcription factor discovered in studies of dioxin
toxicity, are currently elucidated in many laboratories including chemical and microbial …

[HTML][HTML] COVID-19 and cancer comorbidity: therapeutic opportunities and challenges

AS Pathania, P Prathipati, BAA Abdul, S Chava… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory …

Smoking and COVID-19: adding fuel to the flame

VK Kashyap, A Dhasmana, A Massey… - International journal of …, 2020 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, an infection caused by the severe
acute respiratory syndrome coronavirus (SARS-CoV-2), has led to more than 771,000 …

African Americans and European Americans exhibit distinct gene expression patterns across tissues and tumors associated with immunologic functions and …

U Singh, KM Hernandez, BJ Aronow, ES Wurtele - Scientific reports, 2021 - nature.com
The COVID-19 pandemic has affected African American populations disproportionately with
respect to prevalence, and mortality. Expression profiles represent snapshots of combined …

The aryl hydrocarbon receptor promotes inflammation‐induced dedifferentiation and systemic metastatic spread of melanoma cells

M Mengoni, AD Braun, E Gaffal… - International Journal of …, 2020 - Wiley Online Library
The aryl hydrocarbon receptor (AHR) is a ligand binding‐transcription factor of the basic
helix‐loop‐helix family regulating multiple cellular functions such as differentiation, cell …

Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

Z Shen, A Halberg, JY Fong, J Guo, G Song, B Louie… - Scientific Reports, 2022 - nature.com
COVID-19, first reported in late 2019, is an ongoing pandemic that has been causing
devastation across the globe. Although there are multiple vaccines that can prevent severe …

[HTML][HTML] Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

K Hezaveh, RS Shinde, A Klötgen, MJ Halaby… - Immunity, 2022 - cell.com
The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a
potent modulator of immunity. Here, we examined the impact of AhR in tumor-associated …

In vitro profiling of toxic effects of environmental polycyclic aromatic hydrocarbons on nuclear receptor signaling, disruption of endogenous metabolism and induction …

P Šimečková, K Pěnčíková, O Kováč, J Slavík… - Science of The Total …, 2022 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …

Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways

T Haarmann-Stemmann, H Bothe, J Abel - Biochemical pharmacology, 2009 - Elsevier
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant,
which causes a variety of severe health effects, eg immunosuppression, hepatotoxicity, and …

SARS-CoV-2 infection and lung cancer: potential therapeutic modalities

I Gupta, B Rizeq, E Elkord, S Vranic, AE Al Moustafa - Cancers, 2020 - mdpi.com
Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases
with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 …