[HTML][HTML] Recent advances in spatially resolved transcriptomics: challenges and opportunities

J Lee, M Yoo, J Choi - BMB reports, 2022 - ncbi.nlm.nih.gov
Single-cell RNA sequencing (scRNA-seq) has greatly advanced our understanding of
cellular heterogeneity by profiling individual cell transcriptomes. However, cell dissociation …

Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

SK Longo, MG Guo, AL Ji, PA Khavari - Nature Reviews Genetics, 2021 - nature.com
Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …

Advances in spatial transcriptomic data analysis

R Dries, J Chen, N Del Rossi, MM Khan… - Genome …, 2021 - genome.cshlp.org
Spatial transcriptomics is a rapidly growing field that promises to comprehensively
characterize tissue organization and architecture at the single-cell or subcellular resolution …

Navigating the landscapes of spatial transcriptomics: How computational methods guide the way

R Li, X Chen, X Yang - Wiley Interdisciplinary Reviews: RNA, 2024 - Wiley Online Library
Spatially resolved transcriptomics has been dramatically transforming biological and
medical research in various fields. It enables transcriptome profiling at single‐cell, multi …

Deep learning in spatial transcriptomics: Learning from the next next-generation sequencing

AA Heydari, SS Sindi - Biophysics Reviews, 2023 - pubs.aip.org
Spatial transcriptomics (ST) technologies are rapidly becoming the extension of single-cell
RNA sequencing (scRNAseq), holding the potential of profiling gene expression at a single …

An introduction to spatial transcriptomics for biomedical research

CG Williams, HJ Lee, T Asatsuma, R Vento-Tormo… - Genome Medicine, 2022 - Springer
Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over
the past decade, particularly in developmental biology, cancer, immunology, and …

Deep learning in spatial transcriptomics: Learning from the next next-generation sequencing

AA Heydari, SS Sindi - BioRxiv, 2022 - biorxiv.org
Spatial transcriptomics (ST) technologies are rapidly becoming the extension of single-cell
RNA sequencing (scRNAseq), holding the potential of profiling gene expression at a single …

Mapping gene expression in the spatial dimension

Y Chen, W Qian, L Lin, L Cai, K Yin, S Jiang… - Small …, 2021 - Wiley Online Library
The main function and biological processes of tissues are determined by the combination of
gene expression and spatial organization of their cells. RNA sequencing technologies have …

Spatially resolved transcriptomes—next generation tools for tissue exploration

M Asp, J Bergenstråhle, J Lundeberg - Bioessays, 2020 - Wiley Online Library
Recent advances in spatially resolved transcriptomics have greatly expanded the
knowledge of complex multicellular biological systems. The field has quickly expanded in …

Spatial transcriptomics: emerging technologies in tissue gene expression profiling

A Robles-Remacho, RM Sanchez-Martin… - Analytical …, 2023 - ACS Publications
In this Perspective, we discuss the current status and advances in spatial transcriptomics
technologies, which allow high-resolution mapping of gene expression in intact cell and …