Soluble envelope (Env) trimers, stabilized in a prefusion-closed conformation, can elicit
neutralizing responses against HIV-1 strains closely related to the immunizing trimer …

ABSTRACT The HIV-1 envelope (Env) trimer is a target for vaccine design as well as a
conformational machine that facilitates virus entry by transitioning between prefusion-closed …

The heavily glycosylated native-like envelope (Env) trimer of HIV-1 is expected to have low
immunogenicity, whereas misfolded forms are often highly immunogenic. High-quality …

The elicitation of autologous neutralizing responses by immunization with HIV-1 envelope
(Env) trimers conformationally stabilized in a prefusion closed state has generated …

Due to high viral diversity, an effective HIV-1 vaccine will likely require Envs derived from
multiple subtypes to generate broadly neutralizing antibodies (bNAbs). Soluble Env mimics …

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and
neutralization. Despite advances in trimer design, the roots of Env trimer metastability …

Summary The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for
antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies …

The human immunodeficiency virus type 1 (HIV-1) envelope (Env) trimer evades antibody
recognition by adopting a closed prefusion conformation. Here, we show that two conserved …

Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal. Native-
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …

Overcoming envelope metastability is crucial to trimer-based HIV-1 vaccine design. Here,
we present a coherent vaccine strategy by minimizing metastability. For 10 strains across …