Accelerated changes in white matter microstructure during aging: a longitudinal diffusion tensor imaging study
It is well established that human brain white matter structure changes with aging, but the
timescale and spatial distribution of this change remain uncertain. Cross-sectional diffusion …
timescale and spatial distribution of this change remain uncertain. Cross-sectional diffusion …
Age‐related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging
Diffusion tensor imaging (DTI) measures diffusion of molecular water, which can be used to
calculate indices of white matter integrity. Early DTI studies of aging primarily focused on two …
calculate indices of white matter integrity. Early DTI studies of aging primarily focused on two …
White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial statistics
Normal ageing is accompanied by a progressive decline in cognitive function but the
mechanisms for this are not fully understood. Nevertheless, the importance of white matter …
mechanisms for this are not fully understood. Nevertheless, the importance of white matter …
Age-related differences in white matter microstructure: region-specific patterns of diffusivity
We collected MRI diffusion tensor imaging data from 80 younger (20–32 years) and 63 older
(60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that …
(60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that …
White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging
The importance of macrostructural white matter changes, including white matter lesions and
atrophy, in intact brain functioning is increasingly being recognized. Diffusion tensor imaging …
atrophy, in intact brain functioning is increasingly being recognized. Diffusion tensor imaging …
Microstructural white matter changes in normal aging: a diffusion tensor imaging study with higher-order polynomial regression models
JL Hsu, W Van Hecke, CH Bai, CH Lee, YF Tsai… - Neuroimage, 2010 - Elsevier
Diffusion tensor imaging (DTI) has already proven to be a valuable tool when investigating
both global and regional microstructural white matter (WM) brain changes in the human …
both global and regional microstructural white matter (WM) brain changes in the human …
Age-related alterations in white matter microstructure measured by diffusion tensor imaging
Cerebral white matter (WM) undergoes various degenerative changes with normal aging,
including decreases in myelin density and alterations in myelin structure. We acquired …
including decreases in myelin density and alterations in myelin structure. We acquired …
Diffusion tensor imaging of white matter tract evolution over the lifespan
Diffusion tensor imaging (DTI) has been used widely to show structural brain changes
during both development and aging. Lifespan studies are valuable because they connect …
during both development and aging. Lifespan studies are valuable because they connect …
Differential aging of cerebral white matter in middle-aged and older adults: a seven-year follow-up
The few extant reports of longitudinal white matter (WM) changes in healthy aging, using
diffusion tensor imaging (DTI), reveal substantial differences in change across brain regions …
diffusion tensor imaging (DTI), reveal substantial differences in change across brain regions …
White matter in aging and cognition: a cross-sectional study of microstructure in adults aged eighteen to eighty-three
BB Bendlin, ME Fitzgerald, ML Ries, G Xu… - Developmental …, 2010 - Taylor & Francis
Structural brain change and concomitant cognitive decline are the seemingly unavoidable
escorts of aging. Despite accumulating studies detailing the effects of age on the brain and …
escorts of aging. Despite accumulating studies detailing the effects of age on the brain and …