Motivation COVID-19 has several distinct clinical phases: a viral replication phase, an
inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is …

Abstract Background The Coronavirus Disease 2019 (COVID-19) pandemic has infected
over 10 million people globally with a relatively high mortality rate. There are many …

Background Severe coronavirus disease 2019 (COVID-19) has led to severe pneumonia or
acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill …

Dexamethasone, a synthetic glucocorticoid, has previously shown mortality benefit in severe
coronavirus disease 2019 (COVID-19) in a randomized controlled trial. As the illness is …

The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades.
Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease, more commonly
COVID-19 has emerged as a world health pandemic. There are couples of treatment …

To identify key gene expression pathways altered with infection of the novel coronavirus
SARS-CoV-2, we performed the largest comparative genomic and transcriptomic analysis to …

The term cytokine storm refers to an uncontrolled overproduction of soluble inflammatory
markers known as cytokines and chemokines. Autoimmune destruction of the lungs …

Dysregulations in the inflammatory response of the body to pathogens could progress
toward a hyperinflammatory condition amplified by positive feedback loops and associated …

Introduction: Since the emergence of SARS-CoV-2 viruses, multiple mutant strains have
been identified. Infection with SARS-CoV-2 virus leads to alterations in host cell …