Comparison of Helicobacter pylori urease inhibition by rhizoma coptidis, cortex phellodendri and Berberine: mechanisms of interaction with the sulfhydryl group

C Li, J Xie, X Chen, Z Mo, W Wu, Y Liang, Z Su… - Planta …, 2016 - thieme-connect.com
Rhizoma Coptidis, Cortex Phellodendri, and berberine were reported to inhibit Helicobacter
pylori. However, the underlying mechanism remained elusive. Urease plays a vital role in H …

Epiberberine, a natural protoberberine alkaloid, inhibits urease of Helicobacter pylori and jack bean: susceptibility and mechanism

L Tan, C Li, H Chen, Z Mo, J Zhou, Y Liu, Z Ma… - European Journal of …, 2017 - Elsevier
In our previous study, Rhizoma Coptidis extract was found to exert more potent inhibitory
effect than its major component berberine towards urease from Helicobacter pylori (HPU) …

Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression

H Wu, X Xie, Q Tang, T Huang, X Tang, B Jiao… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance With dramatically increasing antibiotic resistance in
Helicobacter pylori (H. pylori), it is urgent to find alternative therapeutic agents. Rhizoma …

Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

C Li, P Huang, K Wong, Y Xu, L Tan… - Journal of enzyme …, 2018 - Taylor & Francis
In this study, we examined the anti-Helicobactor pylori effects of the main protoberberine-
type alkaloids in Rhizoma Coptidis. Coptisine exerted varying antibacterial and bactericidal …

Isolation and characterization of Helicobacter pylori urease inhibitor from Rubus coreanus Miquel

SW Yang, JN Ho, YH Lee, DH Shin… - Journal of the Korean …, 2023 - agris.fao.org
A Helicobacter pylori urease inhibitor from Rubus coreanus Miquel has been isolated and
partially characterized for aiming to prevent H. pylori growth and decrease harmful …

Selective Antibacterial Activity of Patchouli Alcohol Against Helicobacter pylori Based on Inhibition of Urease

XD Yu, JH Xie, YH Wang, YC Li, ZZ Mo… - Phytotherapy …, 2015 - Wiley Online Library
The aim of this study is to evaluate the antibacterial activity and urease inhibitory effects of
patchouli alcohol (PA), the bioactive ingredient isolated from Pogostemonis Herba, which …

Comprehensive evaluation of the anti-Helicobacter pylori activity of scutellariae radix

BW Lee, IIH Park, D Yim… - Natural Product Sciences, 2017 - synapse.koreamed.org
The aim of this study was to evaluate the anti-Helicobacter pylori activity of fractions and
major aglycon compounds (baicalein, chrysin, oroxylin A, wogonin) of Scutellariae Radix …

Inhibition of Helicobacter pylori and Its Associated Urease by Palmatine: Investigation on the Potential Mechanism

JT Zhou, CL Li, LH Tan, YF Xu, YH Liu, ZZ Mo… - PLoS one, 2017 - journals.plos.org
In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory
effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the …

Insight into the inhibitory effects of Zanthoxylum nitidum against Helicobacter pylori urease and jack bean urease: Kinetics and mechanism

Q Lu, C Li, G Wu - Journal of ethnopharmacology, 2020 - Elsevier
Abstract Ethnopharmacological relevance Zanthoxylum nitidum (Roxb.) DC. is a traditional
Chinese medicine characterised by anti-inflammatory and anti-Helicobacter pylori, which is …

Inhibition of urease by extracts derived from 15 Chinese medicinal herbs

DH Shi, YW Liu, WW Liu, ZF Gu - Pharmaceutical Biology, 2011 - Taylor & Francis
Context: Helicobacter pylori is a major causative factor in gastritis-like disorders, and urease
plays a key role in Helicobacter pylori colonizing and persisting in the mucous layer of the …