A predicted operon map for Mycobacterium tuberculosis

P Roback, J Beard, D Baumann, C Gille… - Nucleic acids …, 2007 - academic.oup.com
The prediction of operons in Mycobacterium tuberculosis (MTB) is a first step toward
understanding the regulatory network of this pathogen. Here we apply a statistical model …

REMap: Operon map of M. tuberculosis based on RNA sequence data

S Pelly, K Winglee, F Xia, RL Stevens, WR Bishai… - Tuberculosis, 2016 - Elsevier
A map of the transcriptional organization of genes of an organism is a basic tool that is
necessary to understand and facilitate a more accurate genetic manipulation of the …

A high-resolution network model for global gene regulation in Mycobacterium tuberculosis

EJR Peterson, DJ Reiss, S Turkarslan… - Nucleic acids …, 2014 - academic.oup.com
The resilience of Mycobacterium tuberculosis (MTB) is largely due to its ability to effectively
counteract and even take advantage of the hostile environments of a host. In order to …

Differential gene expression between Mycobacterium bovis and Mycobacterium tuberculosis

G Rehren, S Walters, P Fontan, I Smith, AM Zárraga - Tuberculosis, 2007 - Elsevier
The high sequence identity among the Mycobacterium bovis and Mycobacterium
tuberculosis genomes contrasts with the physiological differences reported between these …

[HTML][HTML] Mapping and manipulating the Mycobacterium tuberculosis transcriptome using a transcription factor overexpression-derived regulatory network

TR Rustad, KJ Minch, S Ma, JK Winkler, S Hobbs… - Genome biology, 2014 - Springer
Background Mycobacterium tuberculosis senses and responds to the shifting and hostile
landscape of the host. To characterize the underlying intertwined gene regulatory network …

[HTML][HTML] Transcriptional Profiling of Mycobacterium Tuberculosis During Infection: Lessons Learned

SK Ward, B Abomoelak, SA Marcus… - Frontiers in …, 2010 - frontiersin.org
Infection with Mycobacterium tuberculosis, the causative agent of tuberculosis, is considered
one of the biggest infectious disease killers worldwide. A significant amount of attention has …

Relaxed selection drives a noisy noncoding transcriptome in members of the Mycobacterium tuberculosis complex

AM Dinan, P Tong, AJ Lohan, KM Conlon… - MBio, 2014 - Am Soc Microbiol
Related species are often used to understand the molecular underpinning of virulence
through examination of a shared set of biological features attributable to a core genome of …

Modeling Bacterial Evolution with Comparative-Genome-Based Marker Systems: Application to Mycobacterium tuberculosis Evolution and Pathogenesis

D Alland, TS Whittam, MB Murray, MD Cave… - Journal of …, 2003 - Am Soc Microbiol
The comparative-genomic sequencing of two Mycobacterium tuberculosis strains enabled
us to identify single nucleotide polymorphism (SNP) markers for studies of evolution …

[HTML][HTML] The DNA-binding network of Mycobacterium tuberculosis

KJ Minch, TR Rustad, EJR Peterson, J Winkler… - Nature …, 2015 - nature.com
Abstract Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone
every 20–30 s. Here we report genome-wide binding for~ 80% of all predicted MTB …

Understanding the host epigenetics in Mycobacterium tuberculosis infection

V Yadav, VP Dwivedi, D Bhattacharya… - Journal of Genetics …, 2015 - repository.ias.ac.in
Epigenetics denotes to study the heritable changes occurred in the gene function without
any changes in DNA sequence. These epigenetic changes are known to be governed by …