Pregnancy loss is the most frequent complication of a pregnancy which is devastating for
affected families and poses a significant challenge for the health care system. Genetic …

Background: Pregnancy loss is the most common obstetric complication occurring in almost
30% of conceptions overall and in 12–14% of clinically recognized pregnancies. Pregnancy …

Approximately 80% of miscarriages happen within the first 12 weeks of gestation. More than
half of early losses result from genetic defects, usually presenting as abnormal chromosome …

Next generation sequencing (NGS) has revolutionized the diagnosis of postnatal genetic
diseases, but so far has been used less frequently to study reproductive disorders. Here we …

Pregnancy loss is a common problem in reproductive-aged women. Although most cases of
pregnancy loss are sporadic, some couples experience recurrent pregnancy loss, a …

Research question What is the genetic cause of sporadic and recurrent pregnancy loss and
does the frequency and nature of chromosomal abnormalities play a role? Types and …

Recurrent pregnancy loss usually results from disorders that cause intrauterine fetal
damage, such as maternal or paternal chromosomal abnormalities. About 15 to 20 percent …

BACKGROUND Approximately 50% of pregnancy losses are caused by chromosomal
abnormalities, such as aneuploidy. The remainder has an apparent euploid karyotype, but it …

Pregnancy loss is one of the most common obstetric complications, affecting over 30% of
conceptions. A considerable proportion of losses are due to genetic abnormalities. Indeed …

Recurrent pregnancy loss is a frequently occurring human infertility-related disease
affecting~ 1% of women. It has been estimated that the cause remains unexplained in> 50 …