The goal of this investigation was to correlate the melanin content in human pigmentary cells
with the generation of UVB‐induced photoproducts and to examine the relationship between …

The question of whether melanins are photoprotecting and/or photosensitizing in human
skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation …

Melanins, pigments of photoprotection and camouflage, are very photoreactive and can both
absorb and emit active oxygen species. Nevertheless, black skinned individuals rarely …

Melanin is thought to serve in photoprotection. To investigate this, we have compared the
responses of cultured human melanocytes derived from different pigmentary phenotypes …

Epidermal melanin pigment is believed to prevent development of ultraviolet (UV)–induced
skin cancer by shielding cell nuclei and reducing DNA damage formation. It has not been …

Melanin can form supranuclear caps in human epidermis, suggesting that intracellular
melanin reduces ultraviolet transmission to underlying cell nuclei and inhibits the formation …

Cultured melanocytes originating from persons with different skin phototypes were utilized
for measurement of endonuclease sensitive sites induced by UVB and the determination of …

Cloudman S91 mouse melanoma cells vary in constitutive and inducible melanin levels.
Survival, mutation induction and DNA damage were quantitated after exposure to UVB, UVA …

Melanin is both photosensitizer and photoprotector. Skin cancer rates decrease with
increasing constitutive pigmentation, yet the pigment has been shown to be photoreactive …

Although the ability of UV irradiation to induce pigmentation in vivo and in vitro is well
documented, the intracellular signals that trigger this response are poorly understood. We …