Airway macrophages (AMs) play key roles in the maintenance of lung immune tolerance.
Tissue tailored, highly specialised and strategically positioned, AMs are critical sentinels of …

As the first line of defence in the lung, alveolar macrophage contributes to maintaining lung
immune homoeostasis. Characterized by the heterogeneity and plasticity, macrophages …

Lung innate immunity is the first line of defence against inhaled allergens, pathogens and
environmental pollutants. Cellular metabolism plays a key role in innate immunity. Catabolic …

Metabolic plasticity involving shifts between mitochondrial respiration and glycolysis is
emerging as a crucial component of innate immune cell function. The number of alveolar …

Macrophage effector function is dynamic in nature and largely dependent on not only the
type of immunological challenge but also the tissue-specific environment and …

Pulmonary macrophages have two distinct ontogenies: long-lived embryonically-seeded
alveolar macrophages (AM) and bone marrow-derived macrophages (BMDM). Here, we …

Alveolar macrophages (AMs) represent a unique leukocyte population that responds to
airborne irritants and microbes. This distinct microenvironment coordinates the maturation of …

Cigarette smoking is a well-known risk factor for pulmonary diseases, including chronic
obstructive pulmonary disease (COPD), asthma and pulmonary fibrosis. Despite major …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

Lung macrophages (LMs) are essential immune effector cells that are pivotal in both innate
and adaptive immune responses to inhaled foreign matter. They either reside within the …