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In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates

S Goutelle, L Bourguignon, N Bleyzac, J Berry… - The AAPS journal, 2013 - Springer
We present a unified quantitative approach to predict the in vivo alteration in drug exposure
caused by either cytochrome P450 (CYP) gene polymorphisms or CYP-mediated drug–drug …
被引用次数：45 相关文章 所有 10 个版本

Genotype‐Based Quantitative Prediction of Drug Exposure for Drugs Metabolized by CYP2D6

M Tod, S Goutelle, MC Gagnieu… - Clinical …, 2011 - Wiley Online Library
We propose a framework to enable quantitative prediction of the impact of CYP2D6
polymorphisms on drug exposure. It relies mostly on in vivo data and uses two characteristic …
被引用次数：26 相关文章 所有 8 个版本

Identification of cytochrome P450-mediated drug–drug interactions at risk in cases of gene polymorphisms by using a quantitative prediction model

N Fermier, L Bourguignon, S Goutelle, N Bleyzac… - Clinical …, 2018 - Springer
Abstract Background and Objective The magnitude of drug–drug interactions mediated by
cytochrome P450 (CYP) may depend on the genotype of polymorphic cytochromes. The …
被引用次数：10 相关文章 所有 4 个版本

Quantitative prediction of the impact of drug interactions and genetic polymorphisms on cytochrome P450 2C9 substrate exposure

AC Castellan, M Tod, F Gueyffier, M Audars… - Clinical …, 2013 - Springer
Abstract Background and Objective Cytochrome P450 (CYP) 2C9 is the most common
CYP2C enzyme and makes up approximately onethird of total CYP protein content in the …
被引用次数：34 相关文章 所有 11 个版本

Quantitative prediction of drug interactions caused by CYP1A2 inhibitors and inducers

L Gabriel, M Tod, S Goutelle - Clinical pharmacokinetics, 2016 - Springer
Background A simple method to predict drug–drug interactions mediated by cytochrome
P450 enzymes (CYPs) on the basis of in vivo data has been previously applied for several …
被引用次数：23 相关文章 所有 9 个版本

Pharmacogenetic prediction of individual variability in drug response based on CYP2D6, CYP2C9 and CYP2C19 genetic polymorphisms

S Rasul Chaudhry, S Muhammad… - Current Drug …, 2014 - ingentaconnect.com
Interindividual variability in drug response depends on a number of genetic and
environmental factors. The metabolic enzymes are well known for their contribution to this …
被引用次数：26 相关文章 所有 5 个版本

The CYP2C19 enzyme polymorphism

PJ Wedlund - Pharmacology, 2000 - karger.com
The genetic test is gradually replacing probe drugs as the primary tool for screening
populations for the CYP2C19 polymorphism. A full appreciation for the clinical and …
被引用次数：236 相关文章 所有 8 个版本

Genetic determinants of drug responsiveness and drug interactions

Y Caraco - Therapeutic drug monitoring, 1998 - journals.lww.com
Six cytochrome P450 enzymes mediate the oxidative metabolism of most drugs in common
use: CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4. These enzymes have …
被引用次数：66 相关文章 所有 6 个版本
[PDF] plos.org

CYP2C9 genotype vs. metabolic phenotype for individual drug dosing—A correlation analysis using flurbiprofen as probe drug

S Vogl, RW Lutz, G Schönfelder, WK Lutz - PLoS One, 2015 - journals.plos.org
Currently, genotyping of patients for polymorphic enzymes responsible for metabolic
elimination is considered a possibility to adjust drug dose levels. For a patient to profit from …
被引用次数：40 相关文章 所有 16 个版本

Prediction of the Effects of Genetic Polymorphism on the Pharmacokinetics of CYP2C9 Substrates from In Vitro Data

M Kusama, K Maeda, K Chiba, A Aoyama… - Pharmaceutical …, 2009 - Springer
Abstract Purpose The* 2 and* 3 alleles of CYP2C9, with decreased enzymatic activity, are
highly polymorphic and contribute to inter-individual differences in pharmacotherapy of …
被引用次数：46 相关文章 所有 11 个版本