Effects of interleukin-10 (IL-10) on pain behavior and gene expression following excitotoxic spinal cord injury in the rat

JA Plunkett, CG Yu, JM Easton, JR Bethea… - Experimental …, 2001 - Elsevier
Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with
pathophysiological characteristics similar to those associated with ischemic and traumatic …

The effects of endogenous interleukin-10 on gray matter damage and the development of pain behaviors following excitotoxic spinal cord injury in the mouse

KE Abraham, D McMillen, KL Brewer - Neuroscience, 2004 - Elsevier
Interleukin-10 (IL-10) has been utilized as a neuroprotective agent in experimental models
of spinal cord injury because of its potent anti-inflammatory properties. Previous studies …

Neuroprotective effects of interleukin-10 following excitotoxic spinal cord injury

KL Brewer, JR Bethea, RP Yezierski - Experimental neurology, 1999 - Elsevier
Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with pathological
characteristics similar to those associated with ischemic and traumatic spinal cord injury …

Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord …

JR Bethea, H Nagashima, MC Acosta… - Journal of …, 1999 - liebertpub.com
In these studies, we examined the neuroprotective effects of the potent antiinflammatory
cytokine interleukin-10 (IL-10) following spinal cord injury (SCI). Neuroprotection was …

Role of IL‐15 in spinal cord and sciatic nerve after chronic constriction injury: regulation of macrophage and T‐cell infiltration

D Gómez‐Nicola, B Valle‐Argos… - Journal of …, 2008 - Wiley Online Library
The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

IL-10 promotes neuronal survival following spinal cord injury

Z Zhou, X Peng, R Insolera, DJ Fink, M Mata - Experimental neurology, 2009 - Elsevier
We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of
signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF …

Interleukin-10 levels in rat models of nerve damage and neuropathic pain

J Khan, K Ramadan, O Korczeniewska, MM Anwer… - Neuroscience …, 2015 - Elsevier
Abstract Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has been shown to play a
role in inflammatory and autoimmune disorders as well as in neuropathic pain conditions …

Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve

P Dubový, V Brázda, I Klusáková… - Journal of …, 2013 - Springer
Background Current research implicates interleukin (IL)-6 as a key component of the
nervous-system response to injury with various effects. Methods We used unilateral chronic …

Absence of endogenous interleukin‐10 enhances secondary inflammatory process after spinal cord compression injury in mice

T Genovese, E Esposito, E Mazzon… - Journal of …, 2009 - Wiley Online Library
Abstract Interleukin‐10 (IL‐10) exerts a wide spectrum of regulatory activities in the immune
and inflammatory response. The aim of this study was to investigate the role of endogenous …

Role of IL-10 in resolution of inflammation and functional recovery after peripheral nerve injury

BS Mietto, A Kroner, EI Girolami… - Journal of …, 2015 - Soc Neuroscience
A rapid proinflammatory response after peripheral nerve injury is required for clearance of
tissue debris (Wallerian degeneration) and effective regeneration. Unlike the CNS, this …