Aims The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque
stabilization in unruptured atherosclerotic plaque and explore its mechanism. Methods and …

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease
endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular …

AIMS: Wall shear stress differentially regulates the arginase pathway in carotid arteries
perfused ex vivo. Specific patterns of wall shear stress can locally determine atherosclerotic …

Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells
(VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This …

The incidence of cardiovascular disease is predicted to increase as the population ages.
There is accumulating evidence that arginase upregulation is associated with impaired …

Objective—Inflammation plays an important role in atherosclerosis. Arginase I (Arg I)
promotes the proliferation of vascular smooth muscle cells; however, the effect of Arg I on …

Background—Although abnormal l-arginine NO signaling contributes to endothelial
dysfunction in the aging cardiovascular system, the biochemical mechanisms remain …

Arginase may play a major role in the regulation of vascular function in various
cardiovascular disorders by impairing nitric oxide (NO) production. In the current study, we …

Arginase upregulation is associated with aging and cardiovascular diseases. In this study
we report on the cardiovascular phenotype of the arginase II knockout (KO) mouse. We …

Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …