Background Arginase competes with nitric oxide synthase for their common substrate L-
arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus …

In the present experiments, we tried to elucidate whether changes in arginase activity and
protein expression of arginase I and II are involved in the occurrence of intimal hyperplasia …

Arginase constrains endothelial nitric oxide synthase activity by competing for the common
substrate, l-Arginine. We have recently shown that inducible nitric oxide synthase (NOS2) S …

Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction
(VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …

Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to
increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …

Endothelial dysfunction is a characteristic feature in diabetes that contributes to the
development of vascular disease. Recently, arginase has been implicated in triggering …

Background—We tested whether tumor necrosis factor (TNF)-α increases arginase
expression in endothelial cells as one of the primary mechanisms by which this inflammatory …

Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown
leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …

Cardiovascular diseases (CVDs) are some of the leading causes of mortality and morbidity
worldwide. They include conditions such as hypertension, coronary artery disease (CAD) …