GV Marinova, RY Loyaga-Rendon… - Journal of …, 2008 - jstage.jst.go.jp
In the present experiments, we tried to elucidate whether changes in arginase activity and protein expression of arginase I and II are involved in the occurrence of intimal hyperplasia …
J Dunn, S Gutbrod, A Webb, A Pak, SK Jandu… - Molecular and cellular …, 2011 - Springer
Arginase constrains endothelial nitric oxide synthase activity by competing for the common substrate, l-Arginine. We have recently shown that inducible nitric oxide synthase (NOS2) S …
Advanced glycation end products (AGEs) contribute significantly to vascular dysfunction (VD) in diabetes. Decreased nitric oxide (NO) is a hallmark in VD. In endothelial cells, NO is …
J Pernow, C Jung - Current vascular pharmacology, 2016 - ingentaconnect.com
Diabetes mellitus is a major risk factor for the development of cardiovascular disease due to increased vascular inflammatory and oxidative stress favouring atherogenesis. Endothelial …
A Mahdi, O Kövamees, J Pernow - International journal of cardiology, 2020 - Elsevier
Endothelial dysfunction represents an early change in the vascular wall in areas prone to atherosclerotic plaque formation and is present in association with several risk factors for …
FK Johnson, RA Johnson, KJ Peyton… - Frontiers in …, 2013 - frontiersin.org
Endothelial dysfunction is a characteristic feature in diabetes that contributes to the development of vascular disease. Recently, arginase has been implicated in triggering …
X Gao, X Xu, S Belmadani, Y Park, Z Tang… - … , and vascular biology, 2007 - Am Heart Assoc
Background—We tested whether tumor necrosis factor (TNF)-α increases arginase expression in endothelial cells as one of the primary mechanisms by which this inflammatory …
T Bachetti, L Comini, G Francolini, D Bastianon… - Journal of molecular and …, 2004 - Elsevier
Objective.–Arginase is a nitric oxide synthase-alternative pathway for l-arginine breakdown leading to biosynthesis of urea and l-ornithine. Arginase pathway is inducible by …
J Moretto, M Pudlo, C Demougeot - Drug Discovery Today, 2021 - Elsevier
Cardiovascular diseases (CVDs) are some of the leading causes of mortality and morbidity worldwide. They include conditions such as hypertension, coronary artery disease (CAD) …