Obesity is associated with development and progression of chronic kidney disease (CKD).
Recent evidence demonstrates that enhanced levels of the L-arginine: ureahydrolase …

Arginase shares a common substrate, L‐arginine, with nitric oxide (NO) synthase (NOS). It is
thought that arginase, if it is expressed in the endothelium, might play a pivotal role in the …

The increase of vascular arginase activity during aging causes endothelial dysfunction. This
enzyme competes with the endothelial nitric oxide synthase (eNOS) for L-arginine substrate …

Primary hypertension is a major risk factor for ischemic heart disease, stroke, and chronic
kidney disease. Insights obtained from the study of rare Mendelian forms of hypertension …

Obesity-induced vascular dysfunction involves pathological remodeling of the visceral
adipose tissue (VAT) and increased inflammation. Our previous studies showed that …

Abstract Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes
the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was …

Although they are implicated on their own as risk factors for cardiovascular disease, the
potential link between nitric oxide (NO) deficiency, ANG II, and vascular stiffening has not …

Objective A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to
endothelial dysfunction and increased peripheral resistances during essential arterial …

Arginine metabolism plays a major role in cardiovascular physiology and pathophysiology,
largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent …

Arterial thrombosis is a common disease leading to severe ischemia beyond the obstructing
thrombus. Additionally, endothelial dysfunction at the site of thrombosis can be rescued by l …