Roads to dysfunction: argininase II contributes to oxidized low-density lipoprotein-induced attenuation of endothelial NO production

RP Brandes - Circulation research, 2006 - Am Heart Assoc
The interaction of oxLDL with cells is mediated by several receptors. 2 Members of the
scavenger receptor family predominate in macrophages, 3 whereas endothelial cells mainly …

Thrombin induces endothelial arginase through AP-1 activation

W Zhu, UM Chandrasekharan… - … of Physiology-Cell …, 2010 - journals.physiology.org
Arterial thrombosis is a common disease leading to severe ischemia beyond the obstructing
thrombus. Additionally, endothelial dysfunction at the site of thrombosis can be rescued by l …

[HTML][HTML] Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis

B Ren, E Van Kampen, TJC Van Berkel… - Atherosclerosis, 2017 - Elsevier
Abstract Background and aims Arginase1 (Arg1), an M2 macrophage marker, plays a critical
role in a number of immunological functions in macrophages, which are the main cell type …

Endothelial arginine resynthesis contributes to the maintenance of vasomotor function in male diabetic mice

R Chennupati, MJ Meens, V Marion, BJ Janssen… - PLoS …, 2014 - journals.plos.org
Aim Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product
of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether …

Pathophysiological correlation of arginase-1 in development of type 2 diabetes from obesity in adolescents

S Mazrouei, SF Petry, F Sharifpanah… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Background There is great interest to understand causal pathophysiological correlation
between obesity and diabetes mellitus (DM). Vascular endothelial dysfunction is crucially …

Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima–media thickness

J Dumont, M Zureik, D Cottel, M Montaye… - Journal of medical …, 2007 - jmg.bmj.com
Background: Recently, it was suggested that arginase (ARG) 1 plays an important role in
atherogenesis. However, because of its complex functions depending on vascular cell type …

Oxidized low‐density lipoprotein inhibits nitric oxide‐mediated coronary arteriolar dilation by up‐regulating endothelial arginase I

W Wang, TW Hein, C Zhang, DC Zawieja… - …, 2011 - Wiley Online Library
Please cite this paper as: Wang, Hein, Zhang, Zawieja, Liao and Kuo (2011). Oxidized Low‐
Density Lipoprotein Inhibits Nitric Oxide‐Mediated Coronary Arteriolar Dilation by Up …

Arginase in the vascular endothelium: friend or foe?

R Lucas, D Fulton, RW Caldwell… - Frontiers in …, 2014 - frontiersin.org
This special issue, entitled “the role of arginase in endothelial dysfunction,” assembles
original contributions (1–4), as well as timely reviews (5–12) broadly related to the …

Arginase inhibition improves endothelial function in patients with coronary artery disease and type 2 diabetes mellitus

A Shemyakin, O Kövamees, A Rafnsson, F Böhm… - Circulation, 2012 - Am Heart Assoc
Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …

Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: the PREVENCION Study

JA Chirinos, R David, JA Bralley, H Zea-Díaz… - …, 2008 - Am Heart Assoc
Endogenous NO synthase inhibitors (end-NOSIs) have been associated with cardiovascular
risk factors and atherosclerosis. In addition, end-NOSIs may directly cause hypertension …