Molecular risk factors for schizophrenia

S Modai, N Shomron - Trends in molecular medicine, 2016 - cell.com
Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also
associated with developmental–environmental triggers. As opposed to most diagnosable …

Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations

WR Reay, MJ Cairns - Translational psychiatry, 2020 - nature.com
The complex aetiology of schizophrenia is postulated to share components with other
psychiatric disorders. We investigated pleiotropy amongst the common variant genomics of …

An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes

TT Chu, Y Liu - Journal of human genetics, 2010 - nature.com
Schizophrenia is a highly complex inheritable disease characterized by numerous genetic
susceptibility elements, each contributing a modest increase in risk for the disease. Although …

Molecular genetic studies of schizophrenia: challenges and insights

C Kato, A Petronis, Y Okazaki, M Tochigi… - Neuroscience …, 2002 - Elsevier
Schizophrenia (SCZ) is a mental disease that affects approximately 1% of the population
with life-long devastating consequences. Based on evidence for a major contribution of …

Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective

CA Dennison, SE Legge, AF Pardinas… - Schizophrenia research, 2020 - Elsevier
Genome-wide association studies (GWAS) have proved to be a powerful approach for gene
discovery in schizophrenia; their findings have important implications not just for our …

Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia

JF Fullard, AW Charney, G Voloudakis… - Translational …, 2019 - nature.com
The genetic architecture of schizophrenia (SCZ) includes numerous risk loci across a range
of frequencies and sizes, including common and rare single-nucleotide variants and …

Genetic correlation profile of schizophrenia mirrors epidemiological results and suggests link between polygenic and rare variant (22q11. 2) cases of schizophrenia

LE Duncan, H Shen, JS Ballon, KV Hardy… - Schizophrenia …, 2018 - academic.oup.com
New methods in genetics research, such as linkage disequilibrium score regression (LDSR),
quantify overlap in the common genetic variants that influence diverse phenotypes. It is …

SZGR: a comprehensive schizophrenia gene resource

P Jia, J Sun, AY Guo, Z Zhao - Molecular psychiatry, 2010 - nature.com
Schizophrenia is a major debilitating psychiatric disorder affecting∼ 1% of the population
worldwide. A tremendous amount of effort has been expended in the last two decades to …

A comprehensive family-based replication study of schizophrenia genes

KA Aberg, Y Liu, J Bukszár, JL McClay… - JAMA …, 2013 - jamanetwork.com
Importance Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the
specific genetic variants and pathways that increase susceptibility to SCZ is critical to …

Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights

M Zamanpoor - Psychiatric genetics, 2020 - journals.lww.com
Schizophrenia is a common multigenic and debilitating neurological disorder characterized
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …