Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia

J Liu, S Li, X Li, W Li, Y Yang, S Guo, L Lv, X Xiao… - BMC medicine, 2021 - Springer
Background Over 200 schizophrenia risk loci have been identified by genome-wide
association studies (GWASs). However, the majority of risk loci were identified in …

[PDF][PDF] Genome-wide association studies in schizophrenia, and potential etiological and functional implications of their results

L Hosák, P Silhan, J Hosáková - Acta Med (Hradec Kralove), 2012 - researchgate.net
Background: despite the fact that the genetic basis of schizophrenia has been intensively
studied for more than two decades, our contemporary knowledge in this field is rather …

Cellular models in schizophrenia research

DA Abashkin, AO Kurishev, DS Karpov… - International journal of …, 2021 - mdpi.com
Schizophrenia (SZ) is a prevalent functional psychosis characterized by clinical behavioural
symptoms and underlying abnormalities in brain function. Genome-wide association studies …

New findings from genetic association studies of schizophrenia

HJ Williams, MJ Owen, MC O'Donovan - Journal of human genetics, 2009 - nature.com
In the past 20 years, association studies of schizophrenia have evolved from analyses in
lesser than 100 subjects of one or two markers in candidate genes to systematic analyses of …

Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery

DA Collier, BJ Eastwood, K Malki… - Annals of the New York …, 2016 - Wiley Online Library
The spectacular advance in our understanding of the genetic basis of schizophrenia through
genome‐wide association studies has the potential to identify new leads for drug treatment …

The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders

A Alkelai, L Greenbaum, AR Docherty… - Molecular …, 2022 - nature.com
Schizophrenia has a multifactorial etiology, involving a polygenic architecture. The potential
benefit of whole genome sequencing (WGS) in schizophrenia and other psychotic disorders …

Genetics of schizophrenia: historical insights and prevailing evidence

J Van de Leemput, JL Hess, SJ Glatt, MT Tsuang - Advances in genetics, 2016 - Elsevier
Abstract Schizophrenia's (SZ's) heritability and familial transmission have been known for
several decades; however, despite the clear evidence for a genetic component, it has been …

Genome‐wide association study of schizophrenia in Ashkenazi Jews

FS Goes, J McGrath, D Avramopoulos… - American Journal of …, 2015 - Wiley Online Library
Schizophrenia is a common, clinically heterogeneous disorder associated with lifelong
morbidity and early mortality. Several genetic variants associated with schizophrenia have …

Genome-wide association study of schizophrenia in Japanese population

K Yamada, Y Iwayama, E Hattori, K Iwamoto, T Toyota… - PloS one, 2011 - journals.plos.org
Schizophrenia is a devastating neuropsychiatric disorder with genetically complex traits.
Genetic variants should explain a considerable portion of the risk for schizophrenia, and …

[PDF][PDF] Schizophrenia genetics comes of age

AC Need, DB Goldstein - Neuron, 2014 - cell.com
The new GWAS from the Schizophrenia Working Group of the Psychiatric Genomics
Consortium (2014) clearly validates a genetic approach to understanding schizophrenia …