Common and rare genetic risk factors converge in protein interaction networks underlying schizophrenia
Hundreds of genomic loci have been identified with the recent advances of schizophrenia in
genome-wide association studies (GWAS) and sequencing studies. However, the functional …
genome-wide association studies (GWAS) and sequencing studies. However, the functional …
Protein-protein interaction and pathway analyses of top schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and …
Recent genome-wide association studies have identified many promising schizophrenia
candidate genes and demonstrated that common polygenic variation contributes to …
candidate genes and demonstrated that common polygenic variation contributes to …
[PDF][PDF] Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia
Genetics have nominated many schizophrenia risk genes and identified convergent signals
between schizophrenia and neurodevelopmental disorders. However, functional …
between schizophrenia and neurodevelopmental disorders. However, functional …
Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling
D Schijven, D Kofink, V Tragante, M Verkerke… - Schizophrenia …, 2018 - Elsevier
Large-scale genome-wide association studies (GWAS) have implicated many low-
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
penetrance loci in schizophrenia. However, its pathological mechanisms are poorly …
Protein interaction networks link schizophrenia risk loci to synaptic function
E Schwarz, R Izmailov, P Liò… - Schizophrenia …, 2016 - academic.oup.com
Schizophrenia is a severe and highly heritable psychiatric disorder affecting approximately
1% of the population. Genome-wide association studies have identified 108 independent …
1% of the population. Genome-wide association studies have identified 108 independent …
[PDF][PDF] Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
Genome-wide association studies (GWASs) have successfully identified 145 genomic
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging …
Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance
Schizophrenia is a serious mental illness, involving disruptions in thought and behavior, with
a worldwide prevalence of about one percent. Although highly heritable, much of the genetic …
a worldwide prevalence of about one percent. Although highly heritable, much of the genetic …
SZDB: a database for schizophrenia genetic research
Y Wu, YG Yao, XJ Luo - Schizophrenia bulletin, 2017 - academic.oup.com
Schizophrenia (SZ) is a debilitating brain disorder with a complex genetic architecture.
Genetic studies, especially recent genome-wide association studies (GWAS), have identified …
Genetic studies, especially recent genome-wide association studies (GWAS), have identified …
Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay
R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
Schizophrenia interactome with 504 novel protein–protein interactions
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare
and common genetic variants, but the functional effects of the risk variants remain to be …
and common genetic variants, but the functional effects of the risk variants remain to be …