Acid-producing stomach parietal cells (PC) are metabolically active and energy demanding
cells. Aberrant PC function and census leads to complications ranging from peptic ulcers to …

Parietal cells (PCs) produce gastric acid to kill pathogens and aid digestion. Dysregulated
PC census is common in disease, yet how PCs differentiate is unclear. Here, we identify the …

The stomach contains gastric epithelial cells, including acid-pumping parietal cells (PCs),
that are constantly renewed throughout life from a multipotent stem cell to maintain a …

Defects in gastric progenitor cell differentiation are associated with various gastric disorders,
including atrophic gastritis, intestinal metaplasia, and gastric cancer. However, the …

Abstract Polycomb Repressive Complexes 1 and 2 (PRC1 and PRC2) control cell identity by
establishing facultative heterochromatin repressive domains at common sets of target …

Gastrointestinal development begins with the formation of a featureless tube known as the
primitive gut tube. Endodermal cells lining the inside of the gut tube differentiate into the …

The intestinal epithelium performs a variety of functions that are essential to maintaining
human health. These processes are carried out by specialized absorptive and secretory cell …

The stomach secretes acid and digestive enzymes, breaks food down mechanically, and is
the site of common diseases including peptic ulcers and cancers. Mechanisms of stomach …

Vertical sleeve gastrectomy (VSG) is one of several bariatric procedures that substantially
improves glycemia and energy homeostasis. Increased secretion of multiple gut peptides …

Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic
energy imbalance, which causes obesity and an increased risk of type 2 diabetes and …