Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice
A Aliluev, S Tritschler, M Sterr, L Oppenländer… - Nature …, 2021 - nature.com
Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic
energy imbalance, which causes obesity and an increased risk of type 2 diabetes and …
energy imbalance, which causes obesity and an increased risk of type 2 diabetes and …
[引用][C] 643 OBESE ADIPOSE TISSUE EXTRACELLULAR VESICLES ACTIVATE FATTY ACID OXIDATION TO DRIVE COLONIC STEMNESS
P Haque, C Couglan, RF Souza, AL Theiss - Gastroenterology, 2024 - Elsevier
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
J Piccand, C Vagne, F Blot, A Meunier, A Beucher… - Molecular …, 2019 - Elsevier
Abstract Objective Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut
luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy …
luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy …
Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation
L Lin, J DeMartino, D Wang, GJF van Son… - Science, 2023 - science.org
Enteroendocrine cells (EECs) are hormone-producing cells residing in the epithelium of
stomach, small intestine (SI), and colon. EECs regulate aspects of metabolic activity …
stomach, small intestine (SI), and colon. EECs regulate aspects of metabolic activity …
Ezh2-dependent epigenetic reprogramming controls a developmental switch between modes of gastric neuromuscular regulation
SA Syed, Y Hayashi, JH Lee, H Yan, A Lorincz… - bioRxiv, 2018 - biorxiv.org
Physiological interconversion between specialized cell types has only been described in a
few mammalian tissues and the mechanisms remain obscure. Using genetic lineage tracing …
few mammalian tissues and the mechanisms remain obscure. Using genetic lineage tracing …
Erbb3 regulation of secretory differentiation in the intestinal epithelium
Background: Previous work by our lab showed that intestinal-specific deletion of the ErbB3
receptor tyrosine kinase results in increased ileal Paneth cell numbers. These cells produce …
receptor tyrosine kinase results in increased ileal Paneth cell numbers. These cells produce …
Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway
ZF Miao, JX Sun, XZ Huang, S Bai, MJ Pang, JY Li… - Developmental Cell, 2024 - cell.com
In pyloric metaplasia, mature gastric chief cells reprogram via an evolutionarily conserved
process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide …
process termed paligenosis to re-enter the cell cycle and become spasmolytic polypeptide …
[HTML][HTML] A metformin-responsive metabolic pathway controls distinct steps in gastric progenitor fate decisions and maturation
Cellular metabolism plays important functions in dictating stem cell behaviors, although its
role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that …
role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that …
PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment
F Chiacchiera, A Rossi, SG Jammula, M Zanotti… - The EMBO …, 2016 - embopress.org
Chromatin modifications shape cell heterogeneity by activating and repressing defined sets
of genes involved in cell proliferation, differentiation and development. Polycomb‐repressive …
of genes involved in cell proliferation, differentiation and development. Polycomb‐repressive …