[HTML][HTML] METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA
L Meng, H Lin, X Huang, J Weng, F Peng, S Wu - Cell death & disease, 2022 - nature.com
Abstract N6-methyladenosine (m6A) is one of the most important epigenetic regulation of
RNAs, such as lncRNAs. However, the underlying regulatory mechanism of m6A in diabetic …
RNAs, such as lncRNAs. However, the underlying regulatory mechanism of m6A in diabetic …
[HTML][HTML] Mettl14 attenuates cardiac ischemia/reperfusion injury by regulating wnt1/β-catenin signaling pathway
P Pang, Z Qu, S Yu, X Pang, X Li, Y Gao… - Frontiers in Cell and …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation in RNA is a dynamic and reversible modification
regulated by methyltransferases and demethylases, which has been reported to participate …
regulated by methyltransferases and demethylases, which has been reported to participate …
[HTML][HTML] Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy
Diabetes cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes
mellitus and is characterized by myocardial fibrosis and myocardial hypertrophy. It has been …
mellitus and is characterized by myocardial fibrosis and myocardial hypertrophy. It has been …
[HTML][HTML] LncRNA KCNQ1OT1 mediates pyroptosis in diabetic cardiomyopathy
Background/Aims: Diabetic cardiomyopathy (DCM) is a common complication of diabetes
and can cause heart failure, arrhythmia and sudden death. The pathogenesis of DCM …
and can cause heart failure, arrhythmia and sudden death. The pathogenesis of DCM …
[HTML][HTML] lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy
We previously established a rat model of diabetic cardiomyopathy (DCM) and found that the
expression of long non-coding RNA myocardial infarction–associated transcript (MIAT) was …
expression of long non-coding RNA myocardial infarction–associated transcript (MIAT) was …
Doxorubicin induces cardiomyocyte pyroptosis via the TINCR-mediated posttranscriptional stabilization of NLR family pyrin domain containing 3
L Meng, H Lin, J Zhang, N Lin, Z Sun, F Gao… - Journal of molecular and …, 2019 - Elsevier
Aims Doxorubicin (DOX), a widely used powerful chemotherapeutic component for cancer
treatment, can give rise to severe cardiotoxicity that limits its clinical use. Pyroptosis is …
treatment, can give rise to severe cardiotoxicity that limits its clinical use. Pyroptosis is …
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
R Gong, X Wang, H Li, S Liu, Z Jiang, Y Zhao… - Pharmacological …, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A), one of the important epigenitic modifications, is
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
Mechanism of METTL3-Mediated m6A Modification in Cardiomyocyte Pyroptosis and Myocardial Ischemia–Reperfusion Injury
X Wang, Y Li, J Li, S Li, F Wang - Cardiovascular drugs and therapy, 2023 - Springer
Objective Myocardial ischemia/reperfusion (MI/R) injury is a complicated pathophysiological
process associated with cardiomyocyte pyroptosis. Methyltransferase-like protein 3 …
process associated with cardiomyocyte pyroptosis. Methyltransferase-like protein 3 …
N6-methyladenosine writer METTL3 accelerates the sepsis-induced myocardial injury by regulating m6A-dependent ferroptosis
H Shen, K Xie, Y Tian, X Wang - Apoptosis, 2023 - Springer
Ferroptosis is an iron-dependent and phospholipid peroxidation-mediated cell death, which
has been identified to be involved in sepsis-induced injury. However, the in-depth molecular …
has been identified to be involved in sepsis-induced injury. However, the in-depth molecular …
LncRNA GAS5 inhibits NLRP3 inflammasome activation-mediated pyroptosis in diabetic cardiomyopathy by targeting miR-34b-3p/AHR
Y Xu, H Fang, Q Xu, C Xu, L Yang, C Huang - Cell Cycle, 2020 - Taylor & Francis
Long noncoding RNA GAS5 is down-regulated in cardiomyocytes in diabetic
cardiomyopathy (DCM). Here, we studied the involvement of GAS5 in DCM by analyzing its …
cardiomyopathy (DCM). Here, we studied the involvement of GAS5 in DCM by analyzing its …