[HTML][HTML] Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey

G Worwa, TK Cooper, S Yeh, JG Shantha… - Communications …, 2022 - nature.com
Despite increasing evidence that uveitis is common and consequential in survivors of Ebola
virus disease (EVD), the host-pathogen determinants of the clinical phenotype are …

[HTML][HTML] Pathogenesis of uveitis in Ebola virus disease survivors: evolving understanding from outbreaks to animal models

C Hartley, JC Bavinger, S Kuthyar, JG Shantha, S Yeh - Microorganisms, 2020 - mdpi.com
Ebola virus disease (EVD) and emerging infectious disease threats continue to threaten life,
prosperity and global health security. To properly counteract EVD, an improved …

Ebola virus tropism in ex vivo cynomolgus macaque ocular tissues

MJ Matson, T Bushmaker, DP Scott… - The Journal of …, 2023 - academic.oup.com
Ocular complications of Ebola virus disease are well-documented and long-term sequelae
in survivors are common and lead to considerable morbidity. However, little is currently …

[HTML][HTML] Retinal pigment epithelial cells are a potential reservoir for Ebola virus in the human eye

JR Smith, S Todd, LM Ashander… - … vision science & …, 2017 - iovs.arvojournals.org
Purpose: Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level
primarily to blockade the host cell type I interferon (IFN) antiviral response. Most individuals …

Characterization of Ebola virus mucosal challenge routes in cynomolgus macaques

DM Johnson, T Brasel, S Massey, J Smith… - Journal of …, 2023 - Am Soc Microbiol
Zaïre ebolavirus (EBOV) causes Ebola virus disease (EVD), a devastating viral hemorrhagic
fever in humans. Nonhuman primate (NHP) models of EVD traditionally use intramuscular …

[HTML][HTML] Ebola virus persistence in ocular tissues and fluids (EVICT) study: reverse transcription-polymerase chain reaction and cataract surgery outcomes of Ebola …

JG Shantha, JG Mattia, A Goba, KG Barnes… - …, 2018 - thelancet.com
Background Ebola virus disease (EVD) survivors are at risk for uveitis during
convalescence. Vision loss has been observed following uveitis due to cataracts. Since …

Clinical manifestations and pathogenesis of uveitis in Ebola virus disease survivors

S Yeh, JG Shantha, B Hayek, I Crozier… - Ocular Immunology and …, 2018 - Taylor & Francis
In the wake of the international Ebola virus disease (EVD) outbreak from 2014 to 2016,
thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic …

[HTML][HTML] Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics

HN Lee, B Xu, AP Lewkowicz, K Engel… - …, 2024 - thelancet.com
Background Ebola virus disease (EVD) survivors experience ocular sequelae including
retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the Ebola …

Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys

X Zeng, CD Blancett, KA Koistinen… - Nature …, 2017 - nature.com
Ebola virus (EBOV) persistence in asymptomatic humans and Ebola virus disease (EVD)
sequelae have emerged as significant public health concerns since the 2013–2016 EVD …

[HTML][HTML] Ebola virus and persistent chronic infection: when does replication cease?

JV Forrester - Annals of Translational Medicine, 2018 - ncbi.nlm.nih.gov
In this issue of the journal, Shantha et al. report a series of cataract surgeries on survivors of
Ebola virus (EBOV) infection. EBOV, originally identified as a new pathogen in 1976 during …