Development of a well-characterized rhesus macaque model of ebola virus disease for support of product development

KJ Alfson, Y Goez-Gazi, M Gazi, H Staples, M Mattix… - Microorganisms, 2021 - mdpi.com
Ebola virus (EBOV) is a negative-sense RNA virus that can infect humans and nonhuman
primates with severe health consequences. Development of countermeasures requires a …

VSV-EBOV rapidly protects macaques against infection with the 2014/15 Ebola virus outbreak strain

A Marzi, SJ Robertson, E Haddock, F Feldmann… - Science, 2015 - science.org
The latest Ebola virus (EBOV) epidemic spread rapidly through Guinea, Sierra Leone, and
Liberia, creating a global public health crisis and accelerating the assessment of …

A glimpse into immune responses evolving against Ebola virus

EO Saphire - Nature Medicine, 2019 - nature.com
A glimpse into immune responses evolving against Ebola virus | Nature Medicine Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo

YJ Ning, Z Kang, J Xing, YQ Min, D Liu, K Feng… - Protein & …, 2018 - academic.oup.com
Ebola virus (EBOV) is one of the most virulent pathogens to humans. Recently, the largest-
ever outbreak of Ebola virus disease (EVD) in West Africa, 2013–2016, resulted in the …

Longitudinal human antibody repertoire against complete viral proteome from Ebola virus survivor reveals protective sites for vaccine design

S Khurana, S Ravichandran, M Hahn, EM Coyle… - Cell host & …, 2020 - cell.com
Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized
in an acutely infected patient receiving supportive care alone to elucidate virus-host …

Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques

KJ Alfson, LE Avena, MW Beadles, H Staples… - Journal of …, 2015 - Am Soc Microbiol
This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence.
Filoviruses are highly lethal, enveloped, single-stranded negative-sense RNA viruses that …

Serologic cross-reactivity of human IgM and IgG antibodies to five species of Ebola virus

A MacNeil, Z Reed, PE Rollin - PLoS neglected tropical diseases, 2011 - journals.plos.org
Five species of Ebola virus (EBOV) have been identified, with nucleotide differences of 30–
45% between species. Four of these species have been shown to cause Ebola hemorrhagic …

Ebola virus vaccines—preparing for the unexpected

HD Klenk, S Becker - Science, 2015 - science.org
The still ongoing Ebola outbreak in West Africa, which began in 2013, and with more than
27,000 cases and 11,000 deaths so far, highlights the need for a vaccine against the …

Extracellular vesicle storm during the course of Ebola virus infection in primates

A Vucetic, A Lafleur, M Côté, D Kobasa… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Ebola virus (EBOV) is an RNA virus of the Filoviridae family that is responsible
for outbreaks of hemorrhagic fevers in primates with a lethality rate as high as 90%. EBOV …

Ocular complications in survivors of the Ebola outbreak in Guinea

E Hereth-Hebert, MO Bah, JF Etard, MS Sow… - American journal of …, 2017 - Elsevier
Purpose The Ebola outbreak of 2013–2016 severely affected West Africa and resulted in
2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was …