Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on‐line configurations for high‐throughput analysis of acidic and basic …

CR Mallet, JR Mazzeo, U Neue - Rapid Communications in …, 2001 - Wiley Online Library
Abstract Several configurations using 6‐and 10‐port switching valves were studied for high
flow, on‐line extraction of rat plasma coupled to an electrospray triple quadrupole mass …

Direct analysis of plasma samples for drug discovery compounds using mixed‐function column liquid chromatography tandem mass spectrometry

Y Hsieh, MS Bryant, G Gruela… - Rapid …, 2000 - Wiley Online Library
A sensitive, efficient, high throughput, direct injection bioanalytical method based on a single
column and high‐performance liquid chromatography (HPLC) with tandem mass …

A new approach to the effective preparation of plasma samples for rapid drug quantitation using on‐line solid phase extraction mass spectrometry

J Ding, UD Neue - Rapid communications in mass …, 1999 - Wiley Online Library
A procedure that permits rapid development of an optimized solid phase extraction (SPE)
method for the analysis of drugs in plasma by on‐line solid phase extraction‐mass …

Direct injection versus liquid‐liquid extraction for plasma sample analysis by high performance liquid chromatography with tandem mass spectrometry

M Jemal, M Huang, X Jiang, Y Mao… - … in mass spectrometry, 1999 - Wiley Online Library
Direct injection versus liquid‐liquid extraction for post‐dose human plasma sample analysis
by high performance liquid chromatography with tandem mass spectrometry (LC/MS/MS) …

On‐line pretreatment using methylcellulose‐immobilized cation‐exchange restricted access media for direct liquid chromatography/mass spectrometric determination …

S Kawano, M Takahashi, T Hine… - … Journal Devoted to …, 2005 - Wiley Online Library
A novel methylcellulose‐immobilized restricted access media column with strong cation‐
exchange groups on an internal surface (MC‐SCX) was evaluated for the direct injection …

A novel on‐line solid‐phase extraction approach integrated with a monolithic column and tandem mass spectrometry for direct plasma analysis of multiple drugs and …

X Zang, R Luo, N Song, TK Chen… - … in Mass Spectrometry …, 2005 - Wiley Online Library
An on‐line solid‐phase extraction liquid chromatography/tandem mass spectrometry (SPE
LC/MS/MS) assay using a newly developed SPE column and a monolithic column was …

Parallel extraction columns and parallel analytical columns coupled with liquid chromatography/tandem mass spectrometry for on‐line simultaneous quantification of a …

YQ Xia, CECA Hop, DQ Liu… - … in Mass Spectrometry, 2001 - Wiley Online Library
A method with parallel extraction columns and parallel analytical columns (PEC‐PAC) for on‐
line high‐flow liquid chromatography/tandem mass spectrometry (LC/MS/MS) was …

The need for adequate chromatographic separation in the quantitative determination of drugs in biological samples by high performance liquid chromatography with …

M Jemal, YQ Xia - Rapid communications in mass spectrometry, 1999 - Wiley Online Library
This work describes real examples of classes of drugs (drug candidates) whose quantitative
determination in biological matrices by high performance liquid chromatography with …

High‐throughput quantification for a drug mixture in rat plasma–a comparison of Ultra Performance™ liquid chromatography/tandem mass spectrometry with high …

K Yu, D Little, R Plumb, B Smith - Rapid Communications in …, 2006 - Wiley Online Library
Abstract A quantitative Ultra Performance™ liquid chromatography/tandem mass
spectrometry (UPL/MS/MS) protocol was developed for a five‐compound mixture in rat …

The development of a staggered parallel separation liquid chromatography/tandem mass spectrometry system with on‐line extraction for high‐throughout screening of …

JT Wu - Rapid Communications in Mass Spectrometry, 2001 - Wiley Online Library
A new parallel liquid chromatography/tandem mass spectrometry (LC/MS/MS) system has
been developed, in which the mass detector was shared between two staggered parallel …